Effects of Bariatric Surgery on Knee Articular Cartilage and Osteoarthritis Symptoms-A 12-Month Follow-Up Using T2 Relaxation Time and WOMAC Osteoarthritis Index

Sami Lehtovirta; Ahti Kemppainen; Marianne Haapea; Mika Nevalainen; Eveliina Lammentausta; Eero Kyllönen; Vesa Koivukangas; Petri Lehenkari; Jaro Karppinen; Victor Casula; Miika T Nieminen

doi:10.1002/jmri.29369

Effects of Bariatric Surgery on Knee Articular Cartilage and Osteoarthritis Symptoms-A 12-Month Follow-Up Using T2 Relaxation Time and WOMAC Osteoarthritis Index

J Magn Reson Imaging. 2024 Apr 1. doi: 10.1002/jmri.29369. Online ahead of print.

Authors

Sami Lehtovirta^{1

2}, Ahti Kemppainen^{1

2}, Marianne Haapea^{2

3

4}, Mika Nevalainen^{1

2

3}, Eveliina Lammentausta^{2

3}, Eero Kyllönen⁵, Vesa Koivukangas⁶, Petri Lehenkari^{2

6

7}, Jaro Karppinen^{1

8

9}, Victor Casula^{1

2}, Miika T Nieminen^{1

2

3}

Affiliations

¹ Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland.
² Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.
³ Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland.
⁴ Research Service Unit, Oulu University Hospital, Oulu, Finland.
⁵ Department of Physical Medicine and Rehabilitation, Oulu University Hospital, Oulu, Finland.
⁶ Department of Surgery, Oulu University Hospital, Oulu, Finland.
⁷ Research Unit of Translational Medicine, University of Oulu, Oulu, Finland.
⁸ Rehabilitation Services of South Karelia Social and Health Care District, Lappeenranta, Finland.
⁹ Finnish Institute of Occupational Health, Oulu, Finland.

PMID: 38558426
DOI: 10.1002/jmri.29369

Abstract

Background: Obesity is a significant risk factor for osteoarthritis (OA). The most effective treatment for morbid obesity is bariatric surgery.

Purpose: To study the effects of potential surgically induced weight loss on knee articular cartilage and OA symptoms of obese patients over a 12-month follow-up.

Study type: Prospective longitudinal cohort study.

Subjects: 45 obese patients (38 female, BMI = 42.3 ± 6.5 kg/m²) who underwent gastric bypass (intervention group), and 46 age-matched conservative-care controls (37 female, BMI = 39.8 ± 4.6 kg/m²).

Field strength/sequence: Multiecho spin echo sequence at 3 T.

Assessment: Knee cartilage T2 measurements and WOMAC Indices were measured presurgery and after 12 months. The intervention group was split into successful (≥20% total weight loss (TWL)) and unsuccessful (<20% TWL) weight loss groups. T2 and WOMAC indices were also measured in controls at baseline and after 12 months. Changes among the three groups were analyzed.

Statistical tests: Analysis of variance (significance level 0.05).

Results: Twenty-six (58%) intervention patients achieved ≥20% TWL. The <20% TWL group demonstrated significantly more T2 reduction in the deep lateral femur over 12 months compared with the ≥20% TWL group (-3.83 ± 8.18 msec vs. 2.47 ± 6.54 msec, respectively), whereas no significant differences were observed on the medial femoral compartment (P = 0.385, P = 0.551, and P = 0.511 for bulk, superficial and deep regions, respectively). Changes in WOMAC indices over 12 months were significantly greater in the ≥20% TWL group compared with controls. In the <20% TWL group, pain significantly improved over 12 months compared with controls, while stiffness and function changes were not statistically significant (P = 0.063 and P = 0.051, respectively).

Data conclusion: Cartilage matrix, measured by T2, showed improvement on lateral femoral cartilage with <20% TWL compared with ≥20% TWL. Bariatric surgery provided significant improvements in knee symptoms with ≥20% TWL compared with conservative WL. This effect is also seen to some extent with <20% TWL compared with conservative WL.

Level of evidence: 2 TECHNICAL EFFICACY: Stage 4.

Keywords: WOMAC; bariatric surgery; cartilage; obesity; osteoarthritis.

Abstract

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