Association of visceral adipose tissue with albuminuria and interaction between visceral adiposity and diabetes on albuminuria

Yufang Liu; Dan Zhao; Sanbao Chai; Xiaomei Zhang

doi:10.1007/s00592-024-02271-8

Association of visceral adipose tissue with albuminuria and interaction between visceral adiposity and diabetes on albuminuria

Acta Diabetol. 2024 Apr 1. doi: 10.1007/s00592-024-02271-8. Online ahead of print.

Authors

Yufang Liu¹, Dan Zhao¹, Sanbao Chai¹, Xiaomei Zhang²

Affiliations

¹ Department of Endocrinology, Peking University International Hospital, Beijing, 102206, People's Republic of China.
² Department of Endocrinology, Peking University International Hospital, Beijing, 102206, People's Republic of China. z.x.mei@163.com.

PMID: 38558152
DOI: 10.1007/s00592-024-02271-8

Abstract

Aims: To explore the correlation between visceral adipose tissue and albuminuria, and whether there is interaction between visceral adipose tissue and diabetes on albuminuria.

Methods: The study subjects were adult subjects (age ≥ 18 years) from the National Health and Nutrition Examination Surveys (NHANES) database of the USA in 2017-2018. Visceral fat area (VFA) was measured by dual-energy X-ray absorptiometry (DXA). Subjects were divided into three groups according to VFA: low (VFA 0-60cm²), medium (VFA 60-120 cm²) and high (VFA ≥ 120 cm²). Albuminuria was defined as urinary albumin-to-creatinine ratio (UACR) ≥ 30 mg/g. The statistical analysis software used is STATA 17.0.

Results: Data pertaining to 2965 participants (2706 without albuminuria) were included in the analysis. High VFA is an independent risk factor for albuminuria (OR 1.367, 95% CI 1.023-1.827). In the low-VFA group, there is no significant association between diabetes and albuminuria (OR 1.415, 95% CI 0.145-13.849). In the medium-VFA group, diabetes is an independent risk factor for albuminuria (OR 2.217, 95% CI 1.095-4.488). In the high-VFA group, diabetes is also an independent risk factor for albuminuria (OR 5.150, 95% CI 3.150-8.421). There is an additive interaction between high VFA (VFA ≥ 120 cm²) and diabetes on the effect of albuminuria (RERI 3.757, 95% CI 0.927-6.587, p = 0.009), while no multiplication interaction (OR 1.881, 95% CI 0.997-1.023, p = 0.141).

Conclusions: High VFA may represent an independent risk factor for albuminuria. The amount of visceral fat may affect the effect of diabetes on albuminuria. The higher the visceral fat, the stronger the correlation between diabetes and albuminuria should be present. We suppose an additive interaction between VFA and diabetes on the effect of albuminuria.

Keywords: Albuminuria; Diabetes; Interaction; Visceral fat.