Natural compounds proposed for the management of non-alcoholic fatty liver disease

Théodora Merenda; Florian Juszczak; Elisabeth Ferier; Pierre Duez; Stéphanie Patris; Anne-Émilie Declèves; Amandine Nachtergael

doi:10.1007/s13659-024-00445-z

Natural compounds proposed for the management of non-alcoholic fatty liver disease

Nat Prod Bioprospect. 2024 Apr 1;14(1):24. doi: 10.1007/s13659-024-00445-z.

Authors

Théodora Merenda¹, Florian Juszczak², Elisabeth Ferier^{2

3}, Pierre Duez³, Stéphanie Patris¹, Anne-Émilie Declèves², Amandine Nachtergael⁴

Affiliations

¹ Unit of Clinical Pharmacy, Research Institute for Health Sciences and Technology, University of Mons (UMONS), Mons, Belgium.
² Department of Metabolic and Molecular Biochemistry, Research Institute for Health Sciences and Technology, University of Mons (UMONS), Mons, Belgium.
³ Unit of Therapeutic Chemistry and Pharmacognosy, Research Institute for Health Sciences and Technology, University of Mons (UMONS), Mons, Belgium.
⁴ Unit of Therapeutic Chemistry and Pharmacognosy, Research Institute for Health Sciences and Technology, University of Mons (UMONS), Mons, Belgium. amandine.nachtergael@umons.ac.be.

Abstract

Although non-alcoholic fatty liver disease (NAFLD) presents as an intricate condition characterized by a growing prevalence, the often-recommended lifestyle interventions mostly lack high-level evidence of efficacy and there are currently no effective drugs proposed for this indication. The present review delves into NAFLD pathology, its diverse underlying physiopathological mechanisms and the available in vitro, in vivo, and clinical evidence regarding the use of natural compounds for its management, through three pivotal targets (oxidative stress, cellular inflammation, and insulin resistance). The promising perspectives that natural compounds offer for NAFLD management underscore the need for additional clinical and lifestyle intervention trials. Encouraging further research will contribute to establishing more robust evidence and practical recommendations tailored to patients with varying NAFLD grades.

Keywords: Chenopodium quinoa; 6-Gingerol; Biochanin A; Curcumin; Ginsenoside K; Hesperidin; Naringenin; Natural compound; Non-alcoholic fatty liver disease; Oleanolic acid; Sylimarin.

Publication types

Review