MICU1's calcium sensing beyond mitochondrial calcium uptake

Sarah D Kaye; Shanikumar Goyani; Dhanendra Tomar

doi:10.1016/j.bbamcr.2024.119714

MICU1's calcium sensing beyond mitochondrial calcium uptake

Biochim Biophys Acta Mol Cell Res. 2024 Mar 29;1871(5):119714. doi: 10.1016/j.bbamcr.2024.119714. Online ahead of print.

Authors

Sarah D Kaye¹, Shanikumar Goyani², Dhanendra Tomar³

Affiliations

¹ Department of Internal Medicine, Section of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
² Department of Internal Medicine, Section of Cardiovascular Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
³ Department of Internal Medicine, Section of Cardiovascular Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: dtomar@wakehealth.edu.

PMID: 38555977
DOI: 10.1016/j.bbamcr.2024.119714

Abstract

The discovery of MICU1 as gatekeeper of mitochondrial calcium (_mCa²⁺) entry has transformed our understanding of _mCa²⁺ flux. Recent studies revealed an additional role of MICU1 as a Ca²⁺ sensor at MICOS (mitochondrial contact site and cristae organizing system). MICU1's presence at MICOS suggests its involvement in coordinating Ca²⁺ signaling and mitochondrial ultrastructure. Besides its role in Ca²⁺ regulation, MICU1 influences cellular signaling pathways including transcription, epigenetic regulation, metabolism, and cell death, thereby affecting human health. Here, we summarize recent findings on MICU1's canonical and noncanonical functions, and its relevance to human health and diseases.

Keywords: Calcium; MCU; MICOS; MICU1; Mitochondria.

Publication types

Review

Grants and funding

R00 DK120876/DK/NIDDK NIH HHS/United States