BMI-based metabolic syndrome severity score and arterial stiffness in a cohort Chinese study

Miao Wang; Chi Wang; Maoxiang Zhao; Shouling Wu; Hao Xue; Hongbin Liu

doi:10.1016/j.numecd.2024.02.012

BMI-based metabolic syndrome severity score and arterial stiffness in a cohort Chinese study

Nutr Metab Cardiovasc Dis. 2024 Feb 29:S0939-4753(24)00083-8. doi: 10.1016/j.numecd.2024.02.012. Online ahead of print.

Authors

Miao Wang¹, Chi Wang², Maoxiang Zhao², Shouling Wu³, Hao Xue⁴, Hongbin Liu⁵

Affiliations

¹ The School of Medicine, Nankai University, No.94 Weijin Road, Nankai District, Tianjin 300071, China; Department of Cardiology, Chinese People's Liberation Army General Hospital, No.28 Fuxing Road, Beijing 100853, China.
² Department of Cardiology, Chinese People's Liberation Army General Hospital, No.28 Fuxing Road, Beijing 100853, China.
³ Department of Cardiology, Kailuan Hospital, Hebei United University, Tangshan 063001, China.
⁴ Department of Cardiology, Chinese People's Liberation Army General Hospital, No.28 Fuxing Road, Beijing 100853, China. Electronic address: xuehaoxh301@163.com.
⁵ Department of Cardiology, Chinese People's Liberation Army General Hospital, No.28 Fuxing Road, Beijing 100853, China. Electronic address: liuhbcad301@163.com.

PMID: 38555245
DOI: 10.1016/j.numecd.2024.02.012

Abstract

Background and aims: To investigate the relationship between metabolic syndrome severity z score(MetS-Z) and arterial stiffness(AS).

Methods and results: A total of 7621 participants who took three physical examination and brachial-ankle pulse wave velocity(ba-pwv) test from 2006 were enrolled. Cumulative MetS-Z(cMetS-Z) was calculated by using blood pressure, triglycerides, HDL cholesterol, blood glucose and BMI. AS was assessed by ba-pwv. Cox regression model was used to evaluate the risk of AS. All the participants were divided into four groups according to cMetS-Z(Q1-Q4). The average age of the participants was 43.06 ± 8.91 years old. During a median follow-up of 6.27 years, 1831cases of AS was identified. The incident rate of AS increased gradually from group Q1 to Q4. Compared with the lowest cMetS-Z(group Q1), the adjusted hazard ratio (HR) and 95% confidence interval (CI) of group Q2-Q4 for AS were 1.27 (1.09-1.47),1.28(1.10-1.48) and 1.45 (1.24-1.69) respectively. The cubic spline model indicated cMetS-Z had a liner relationship with AS and the cut-off value was lower than zero. Sub-group analysis suggested cMetS-Z was related to AS especially among participants who were younger and without obesity or hypertension or diabetes.

Conclusion: Higher cMetS-Z was associated with an increased risk of AS in this cohort community study, and this relationship seemed to be stronger among normal healthy subjects.

Registration number: ChiCTR-TNC-11001489.

Clinical trial: January 1st 2006, ChiCTR-TNC-11001489 and 2011.

Keywords: Arterial stiffness; Atherosclerosis; Brachial-ankle pulse wave velocity; Metabolic syndrome; Metabolic syndrome severity score; Obesity.