Dietary advanced glycation end products, body composition, and anthropometric measures: A cross-sectional analysis in women with excess body weight

Nélia P Mendes; Flávia G Cândido; Flávia X Valente; Maria do Carmo G Peluzio; Leidjaira L Juvanhol; Rita C G Alfenas

doi:10.1016/j.numecd.2024.03.011

Dietary advanced glycation end products, body composition, and anthropometric measures: A cross-sectional analysis in women with excess body weight

Nutr Metab Cardiovasc Dis. 2024 Mar 12:S0939-4753(24)00113-3. doi: 10.1016/j.numecd.2024.03.011. Online ahead of print.

Authors

Nélia P Mendes¹, Flávia G Cândido², Flávia X Valente², Maria do Carmo G Peluzio², Leidjaira L Juvanhol², Rita C G Alfenas²

Affiliations

¹ Department of Nutrition and Health, Universidade Federal de Viçosa, Campus Universitário, s/nº, Av. Peter Henry Rolfs, Centro, 35570-900, Viçosa, MG, Brazil. Electronic address: nelia.mendes@ufv.br.
² Department of Nutrition and Health, Universidade Federal de Viçosa, Campus Universitário, s/nº, Av. Peter Henry Rolfs, Centro, 35570-900, Viçosa, MG, Brazil.

PMID: 38555239
DOI: 10.1016/j.numecd.2024.03.011

Abstract

Background and aims: To assess the association between dietary advanced glycation end products (dAGEs) versus body composition and anthropometric variables.

Methods and results: Body composition (dual-energy X-ray absorptiometry), anthropometry, and habitual food intake were cross-sectionally evaluated in women with excess body weight and body fat. Mean dAGEs content was estimated using a database containing the N^ԑ-(carboxymethyl)lysine (CML) content of 549 foods, which was adjusted by mean energy intake, and categorized into low, medium, and high dAGEs, by the 10th and 50th percentiles of the sample. Associations were tested by linear regression adjusted for age, education, marital status, and physical activity level. Eighty participants had mean ± standard deviation dAGEs 7.85 ± 2.65 AGEs kU/kcal. Compared with high dAGEs, women with low dAGEs ingested more carbohydrate (62% vs. 50% of calories, p < 0.001) and fiber (≈25 g vs. ≈18 g, p = 0.027) and less protein (13% vs. 17% of calories, p = 0.006) and fat (26% vs. 33% of calories, p = 0.011). Women with low dAGEs had waist/hip ratio 0.05 higher than those with high dAGEs (R² = 0.256, p = 0.005). Low dAGEs relative to medium (p = 0.009) and high (p = 0.002) dAGEs was associated with a ≈5% gynoid fat reduction (R² = 0.164).

Conclusion: Low dAGEs was associated with a higher waist/hip ratio and lower percentage of gynoid fat in women with excess body weight and excess body fat.

Registration number: RBR-7z358j.

Keywords: Abdominal obesity; Advanced glycation end products; Body fat; Food record; Habitual intake.

Copyright © 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.