Synthesis on NIR-II Multifunctional Imaging and Photothermal Therapy of a Novel Water-Soluble Molecule

Mengyu Cao; Chang Wang; Fang Wang; Wentao Zou; Bing Yu; Hailin Cong; Youqing Shen

doi:10.1002/adhm.202304564

Synthesis on NIR-II Multifunctional Imaging and Photothermal Therapy of a Novel Water-Soluble Molecule

Adv Healthc Mater. 2024 Mar 29:e2304564. doi: 10.1002/adhm.202304564. Online ahead of print.

Authors

Mengyu Cao¹, Chang Wang¹, Fang Wang¹, Wentao Zou¹, Bing Yu^{1

2}, Hailin Cong^{1

2

3}, Youqing Shen^{1

4}

Affiliations

¹ College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao, 266071, China.
² State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao, 266071, China.
³ School of Materials Science and Engineering, Shandong University of Technology, Zibo, 255000, China.
⁴ Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Center for Bionanoengineering, and Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang, 310027, China.

PMID: 38552668
DOI: 10.1002/adhm.202304564

Abstract

The synthesis of water-soluble symmetric molecules with donor-acceptor-donor (D-A-D) structure is reported. The compound is connected by π bridge with 2-bromofluorene external polyethylene glycol 2000 as the shielding unit, and donor component and pyrrolopyrrole (DPP) as the acceptor unit. The D-A-D double donor fluorescent molecule P2-DPP is obtained by coupling reaction. The absorption peak and emission peak of the fluorescent molecule P2-DPP are 600 and 1020 nm, respectively. It has potential excellent imaging characteristics. It does not need to use nanoparticles formed by the DSPE-MPEG amphiphilic block to form micelles. The quantum yield reaches 0.6% and the penetration depth can reach 10 mm. The chemical is capable of achieving liver and renal metabolism. It has a good application prospect in the photothermal therapy of mouse tumors and realizes the integration of biological diagnosis and treatment.

Keywords: biocompatibility; near‐infrared second region; photothermal therapy; water solubility.

Abstract

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