Life-Threatening Thrombosis After Large Amounts of Nitrous Oxide Use

Gustaf McMahon; Frida Lönnberg; Gargi Gautam; Anna Ågren; Johanna Nordmark Grass; Anwar J Siddiqui

doi:10.1016/j.jaccas.2024.102312

Life-Threatening Thrombosis After Large Amounts of Nitrous Oxide Use

JACC Case Rep. 2024 Mar 21;29(9):102312. doi: 10.1016/j.jaccas.2024.102312. eCollection 2024 May 1.

Authors

Gustaf McMahon¹, Frida Lönnberg^{1

2}, Gargi Gautam^{3

4}, Anna Ågren^{5

6}, Johanna Nordmark Grass⁷, Anwar J Siddiqui^{1

2}

Affiliations

¹ Acute and Reparative Medicine Theme, Karolinska University Hospital, Stockholm, Sweden.
² Department of Medicine, Karolinska Institute, Solna, Sweden.
³ Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute, Stockholm, Sweden.
⁴ Department of Internal Medicine, Danderyd Hospital, Danderyd, Sweden.
⁵ Coagulation Unit, Department of Hematology, Karolinska University Hospital, Stockholm, Sweden.
⁶ Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
⁷ Swedish Poisons Information Centre, Solna, Sweden.

Abstract

This case report highlights the development of severe, life-threatening thrombotic complications after chronic recreational use of large quantities of nitrous oxide in a 21-year-old patient. In young patients presenting with thromboembolism and nitrous oxide abuse, swift identification of symptoms and management is critical.

Keywords: homocysteine; nitrous oxide; pulmonary embolism; stroke; thromboembolism; vitamin B12.

Publication types

Case Reports