Background: Long non-coding RNA (LncRNA) is a type of non-coding RNA that plays an important role in the body and accounts for the majority of RNA, and this non-coding RNA can regulate disease onset and progression with its wide range of functions. LncRNA Xist, also known as the long non-coding RNA X inactive specific transcript, is a member of them. It can regulate the development of organismal diseases by acting downstream on specific target genes. In addition to this, it can also influence disease onset and progression by acting on apoptosis, migration, invasion, and other processes. It has been shown that XIST plays an important role in the development of inflammation.
Objective: To explore the role played by XIST in inflammation-related diseases and to explore its mechanism of action.
Methods: This paper summarizes and analyzes the role played by XIST in inflammation- related diseases by conducting a search in PubMed.
Conclusion: In this paper, we summarize the mechanism of action of XIST in different types of inflammation-related diseases and propose new protocols for the future clinical treatment of these diseases.
Keywords: Long non-coding RNA; XIST; ceRNA; inflammation; mechanism; miRNA.
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