Tumor-associated fibrosis: a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination

Hiroki Fujimoto; Masato Yoshihara; Raymond Rodgers; Shohei Iyoshi; Kazumasa Mogi; Emiri Miyamoto; Sae Hayakawa; Maia Hayashi; Satoshi Nomura; Kazuhisa Kitami; Kaname Uno; Mai Sugiyama; Yoshihiro Koya; Yoshihiko Yamakita; Akihiro Nawa; Atsushi Enomoto; Carmela Ricciardelli; Hiroaki Kajiyama

doi:10.1007/s10555-024-10169-8

Tumor-associated fibrosis: a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination

Cancer Metastasis Rev. 2024 Mar 28. doi: 10.1007/s10555-024-10169-8. Online ahead of print.

Authors

Hiroki Fujimoto^{1

2}, Masato Yoshihara³, Raymond Rodgers⁴, Shohei Iyoshi^{1

5}, Kazumasa Mogi¹, Emiri Miyamoto¹, Sae Hayakawa¹, Maia Hayashi¹, Satoshi Nomura¹, Kazuhisa Kitami⁶, Kaname Uno^{1

7}, Mai Sugiyama⁸, Yoshihiro Koya⁸, Yoshihiko Yamakita⁸, Akihiro Nawa⁸, Atsushi Enomoto⁹, Carmela Ricciardelli¹⁰, Hiroaki Kajiyama¹

Affiliations

¹ Department of Obstetrics and Gynaecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
² Discipline of Obstetrics and Gynaecology, Adelaide Medical School, Robinson Research Institute, University of Adelaide, Adelaide, Australia.
³ Department of Obstetrics and Gynaecology, Nagoya University Graduate School of Medicine, Nagoya, Japan. myoshihara1209@med.nagoya-u.ac.jp.
⁴ School of Biomedicine, Robinson Research Institute, The University of Adelaide, Adelaide, Australia.
⁵ Spemann Graduate School of Biology and Medicine, University of Freiburg, Freiburg im Breisgau, Germany.
⁶ Department of Obstetrics and Gynaecology, Kitasato University School of Medicine, Sagamihara, Japan.
⁷ Division of Clinical Genetics, Department of Laboratory Medicine, Lund University Graduate School of Medicine, Lund, Sweden.
⁸ Bell Research Center-Department of Obstetrics and Gynaecology Collaborative Research, Nagoya University Graduate School of Medicine, Nagoya, Japan.
⁹ Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
¹⁰ Discipline of Obstetrics and Gynaecology, Adelaide Medical School, Robinson Research Institute, University of Adelaide, Adelaide, Australia. carmela.ricciardelli@adelaide.edu.au.

PMID: 38546906
DOI: 10.1007/s10555-024-10169-8

Abstract

Epithelial ovarian cancer (EOC) is often diagnosed in advanced stage with peritoneal dissemination. Recent studies indicate that aberrant accumulation of collagen fibers in tumor stroma has a variety of effects on tumor progression. We refer to remodeled fibrous stroma with altered expression of collagen molecules, increased stiffness, and highly oriented collagen fibers as tumor-associated fibrosis (TAF). TAF contributes to EOC cell invasion and metastasis in the intraperitoneal cavity. However, an understanding of molecular events involved is only just beginning to emerge. Further development in this field will lead to new strategies to treat EOC. In this review, we focus on the recent findings on how the TAF contributes to EOC malignancy. Furthermore, we will review the recent initiatives and future therapeutic strategies for targeting TAF in EOC.

Keywords: Extracellular matrix; Fibrosis; Mesothelial; Metastasis; Ovarian cancer.

Publication types

Review

Abstract

Publication types

Grants and funding