Sleep Restfulness in Patients with Obstructive Sleep Apnea Undergoing Continuous Positive Airway Pressure Therapy

Satoshi Hamada; Jumpei Togawa; Hironobu Sunadome; Tadao Nagasaki; Naomi Takahashi; Toyohiro Hirai; Susumu Sato

doi:10.1055/s-0043-1776741

Sleep Restfulness in Patients with Obstructive Sleep Apnea Undergoing Continuous Positive Airway Pressure Therapy

Sleep Sci. 2024 Feb 15;17(1):e37-e44. doi: 10.1055/s-0043-1776741. eCollection 2024 Mar.

Authors

Satoshi Hamada¹, Jumpei Togawa², Hironobu Sunadome², Tadao Nagasaki², Naomi Takahashi², Toyohiro Hirai³, Susumu Sato²

Affiliations

¹ Department of Advanced Medicine for Respiratory Failure, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
² Department of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
³ Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Abstract

Objective Sleep restfulness is closely associated with mortality. Thus, it is an important sleep-related symptom in the general population. However, it is rarely evaluated in patients with obstructive sleep apnea (OSA) syndrome. The present study examined the importance of sleep restfulness in patients with OSA receiving continuous positive airway pressure (CPAP) therapy. Materials and Methods We administered sleep-related questionnaires, which included items such as subjective sleep duration and sleep restfulness, to 775 patients with OSA receiving CPAP therapy. Sleep restfulness was rated using a 5-point Likert-type scale, with the score of 5 indicating restfulness. Good adherence to CPAP therapy was defined as the use of CPAP therapy for at least 4 h per night in 70% of nights. Results We excluded 105 patients with lacking data. Thus, 670 patients were finally examined. In total, 29 (4.3%), 124 (18.5%), 139 (20.8%), 235 (35.1%), and 143 (14.3%) patients answered restless (1), somewhat restless (2), neither (3), somewhat restful (4), and restful (5) respectively. A total of 467 (69.7%) patients had good adherence to CPAP therapy. Multivariate logistic regression analysis showed that sleep restfulness was independently and positively associated with subjective sleep duration (≥ 7 hours) and good adherence to CPAP therapy. Conclusion Sleep restfulness was associated with subjective sleep duration and good adherence to CPAP therapy in patients with OSA. Favorable outcomes are significantly correlated with good adherence to CPAP therapy. Thus, sleep restfulness can be an indicator of a subtype that has favorable outcomes in patients after CPAP therapy.

Keywords: continuous positive airway pressure; obstructive sleep apnea; surveys and questionnaires.

Brazilian Sleep Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).

Grants and funding

Funding The Department of Advanced Medicine for Respiratory Failure is a Department of Collaborative Research Laboratory funded by Teijin Pharma. The Department of Respiratory Care and Sleep Control Medicine is funded by endowments from Philips Japan, ResMed Japan, Fukuda Denshi and Fukuda Lifetec-Keiji to Kyoto University. This study was funded in part by the JSPS KAKENHI 22K16169 (SH).