Safety of fasting in diabetic and non-diabetic patients with stable chronic kidney disease during Ramadan

Anita Haroon; Musarrat Riaz; Bushra Rabbani; Ammarah Saeed

doi:10.12669/pjms.40.4.7989

Safety of fasting in diabetic and non-diabetic patients with stable chronic kidney disease during Ramadan

Pak J Med Sci. 2024 Mar-Apr;40(4):563-567. doi: 10.12669/pjms.40.4.7989.

Authors

Anita Haroon¹, Musarrat Riaz², Bushra Rabbani³, Ammarah Saeed⁴

Affiliations

¹ Dr. Anita Haroon, MRCP , FCPS (Nephrology), FRCP Assistant Professor, Department of Nephrology, Baqai Medical University, Karachi, Pakistan.
² Dr. Musarrat Riaz, FCPS (Med), FCPS (Endocrinology). Associate Professor, Department of Medicine, Baqai Medical University, Karachi, Pakistan.
³ Dr. Bushra Rabbani, FCPS. Assistant Professor, Department of Medicine, Baqai Medical University, Karachi, Pakistan.
⁴ Dr. Ammarah Saeed, FCPS. Assistant Professor, Department of Medicine, Fazaia Medical College, Karachi, Pakistan.

Abstract

Objective: To assess the safety of fasting in diabetic and non-diabetic patients with stable CKD during Ramadan.

Methods: This prospective observational study was conducted at three secondary and tertiary care hospitals of Karachi during the month of Ramadan from 25^th March to 7^th May 2022. Patients who met the eligibility criteria were assessed pre-Ramadan, and their baseline blood pressure, serum urea, creatinine, electrolytes, uric acid, and estimated glomerular filtration rate (eGFR) were documented and tracked over the course of Ramadan and up to one week post-Ramadan. Deterioration in renal functions (defined as a rise of ≥30% in serum creatinine from the baseline or the decline of ≥25% in eGFR from the baseline) was observed during the month of Ramadan.

Results: A total of 68 patients (34 males and 32 females) with the mean age 58.7±12.16 years were included in the study. Out of 66 patients, 38 were diabetic and 28 were non diabetic. Majority 23(34.8%) were stage-3a and 23(34.8%) were stage-4 followed by stage-3b in 14(21.2%), stage-2 in 3(4.5%) and stage-5 in 3(4.5%) patients respectively. Statistically significant improvement in pre and post Ramadan values of systolic and diastolic blood pressure, serum creatinine and uric acid levels were found in both diabetic and non-diabetic group (P value <0.0001).

Conclusion: Our study shows no worsening of renal functions in both diabetic and non-diabetic patients with stable CKD who intended to fast.

Keywords: Fasting; Ramadan; Stable CKD; eGFR.