The Effect of Surgical Procedure in the Nasal Cavity on the Passive Avoidance Conditioning and the Hypothalamic Level of Monoamines in Rats

A G Korolev; I V Kastyro; A N Inozemtsev; A V Latanov

doi:10.1134/S0012496624700959

The Effect of Surgical Procedure in the Nasal Cavity on the Passive Avoidance Conditioning and the Hypothalamic Level of Monoamines in Rats

Dokl Biol Sci. 2024 Mar 27. doi: 10.1134/S0012496624700959. Online ahead of print.

Authors

A G Korolev^{1

2}, I V Kastyro³, A N Inozemtsev⁴, A V Latanov⁴

Affiliations

¹ Biological Faculty, Moscow State University, Moscow, Russia. korolevpost@gmail.com.
² Medical Institute, Peoples' Friendship University of Russia, Moscow, Russia. korolevpost@gmail.com.
³ Medical Institute, Peoples' Friendship University of Russia, Moscow, Russia.
⁴ Biological Faculty, Moscow State University, Moscow, Russia.

PMID: 38538826
DOI: 10.1134/S0012496624700959

Abstract

A rat biological model of septoplasty was used to study the effect of surgery on passive avoidance conditioning (PAC). Septoplasty was shown to increase anxiety and to reduce exploratory activity in rodents during PAC. A neurochemical analysis of the hypothalamus was carried out immediately after the end of the experiment and showed an increase in norepinephrine (NE) metabolism after septoplasty. The finding was tentatively associated with activation of the hypothalamic-pituitary-adrenal axis.

Keywords: memory; norepinephrine; passive avoidance; rats; septoplasty; stress.