Long-term inhalation of silica dust can cause silicosis, but also may induce autoimmune diseases, such as systemic sclerosis, rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome, anti-histidyl tRNA synthetase antibody (JO-1 antibody) syndrome. These two diseases can be isolated or combined. In this paper, the clinical characteristics of 5 cases of silicosis complicated with connective tissue diseases were analyzed and summarized to strengthen the clinical understanding of silicosis complicated with connective tissue diseases, so as to reduce its misdiagnosis and missed diagnosis, and provide reference for clinicians in diagnosis and treatment.
长期吸入矽尘可引起矽肺，同时也可能诱发自身免疫性疾病，如系统性硬化症、类风湿性关节炎、系统性红斑狼疮、干燥综合征、抗组氨酰tRNA合成酶抗体（JO-1抗体）综合征等。上述两种疾病可单独发病，也可合并存在。本文通过对5例矽肺合并结缔组织疾病患者的临床特点进行分析及总结，加强临床上对矽肺合并结缔组织疾病的认识能力，从而减少其误诊漏诊，为临床医师诊治提供参考。.
Keywords: Clinical analysis; Connective tissue diseases; Silicosis.