Amniotic membrane transplantation as part of a multimodal management approach to Streptococcus pyogenes necrotizing keratoconjunctivitis

Kelly L Ruland; Natalya Beneschott; C Buddy Creech; Allison Umfress

doi:10.1016/j.jaapos.2024.103900

Amniotic membrane transplantation as part of a multimodal management approach to Streptococcus pyogenes necrotizing keratoconjunctivitis

J AAPOS. 2024 Mar 25:103900. doi: 10.1016/j.jaapos.2024.103900. Online ahead of print.

Authors

Kelly L Ruland¹, Natalya Beneschott², C Buddy Creech², Allison Umfress³

Affiliations

¹ Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: Rulandkelly1@gmail.com.
² Vanderbilt Vaccine Research Program, Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
³ Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.

PMID: 38537895
DOI: 10.1016/j.jaapos.2024.103900

Abstract

Streptococcus pyogenes (group A beta-hemolytic Streptococcus, GABHS) causes a range of human infections, including necrotizing fasciitis and toxic shock syndrome, because it produces exotoxins that damage host cells, facilitate immune evasion, and serve as T cell superantigens. GABHS conjunctivitis is rare. We report a case of membranous conjunctivitis in a 3-year-old child who was treated with a combination of targeted bactericidal antimicrobials, toxin-synthesis inhibition, and amniotic membrane transplantation.

Publication types

Case Reports