Occult SMARCA4-Deficient Undifferentiated Carcinoma Unmasked by 68Ga-FAPI-46 PET/CT

Weizhi Xu; Long Zhao; Jiayu Cai; Haojun Chen

doi:10.1097/RLU.0000000000005191

Occult SMARCA4-Deficient Undifferentiated Carcinoma Unmasked by 68Ga-FAPI-46 PET/CT

Clin Nucl Med. 2024 Mar 25. doi: 10.1097/RLU.0000000000005191. Online ahead of print.

Authors

Weizhi Xu¹, Long Zhao, Jiayu Cai, Haojun Chen

Affiliation

¹ From the Department of Nuclear Medicine & Minnan PET Center, Xiamen Cancer Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.

PMID: 38537213
DOI: 10.1097/RLU.0000000000005191

Abstract

SMARCA4-deficient undifferentiated tumors (SMARCA4-dUT) are rare and aggressive neoplasms commonly found in male smokers and portend a poor prognosis. In this case, we reported 18F-FDG and 68Ga-FAPI-46 PET/CT findings in an occult SMARCA4-dUT located in the left pulmonary hilum along with mediastinal lymph node metastases. 68Ga-FAPI-46 PET/CT showed superiority over 18F-FDG for detecting SMARCA4-dUT lesions. This case highlighted that 68Ga-FAPI-46 PET/CT may be a promising imaging modality in the evaluation of SMARCA4-dUT, particularly for detecting the occult SMARCA4-dUT arising in uncommon sites.