18F-FET PET/CT in Calcifying Pseudoneoplasm of the Neuraxis: First Case

Demetrio Aricò; Giulia Giacoppo; Michelangelo Bambaci; Lorenza Marino; Andrea Girlando; Giuseppe Sortino; Giorgia Leone; Bethania Fernandes; Marco Alì; Laura Evangelista; Alberto Romano

doi:10.1097/RLU.0000000000005197

18F-FET PET/CT in Calcifying Pseudoneoplasm of the Neuraxis: First Case

Clin Nucl Med. 2024 Mar 25. doi: 10.1097/RLU.0000000000005197. Online ahead of print.

Authors

Affiliations

¹ From the Nuclear Medicine Service.
² Radiotherapy Service.
³ Diagnostic Neuroradiology Service, and.
⁴ Pathology Section, Humanitas Istituto Clinico Catanese, Misterbianco.
⁵ Humanitas Clinical and Research Center, IRCSS, Rozzano.
⁶ Medical Oncology Unit, Humanitas Istituto Clinico Catanese, Catania.
⁷ Department of Biomedical Science, Humanitas University, Milan.
⁸ Neurosurgery Unit, Humanitas Istituto Clinico Catanese, Misterbianco, Italy.

PMID: 38537205
DOI: 10.1097/RLU.0000000000005197

Abstract

A 66-year-old man has been treated in a psychiatric department for 4-5 years for a depressive syndrome, which is associated with poor motor initiative, confusional state, and dysosmia. Dynamic 18F-FET PET/CT showed only faint uptake of radiotracer just above the background on the left frontal calcific lesion. The time-activity curve of the neoplasms showed a descending pattern. After a left fronto-orbitary minicraniotomy surgery, histology examination concluded for a rare calcifying pseudoneoplasm of the neuraxis (CAPNON). To our knowledge, no data are available on the metabolic behavior of CAPNON in 18F-FET PET/CT. This case highlighted that a faint uptake and descending pattern on dynamic 18F-FET PET/CT may be helpful in suspected CAPNON before surgery.