Marine Bromotyrosine Derivatives in Spotlight: Bringing Discoveries and Biological Significance

Mar Drugs. 2024 Mar 14;22(3):132. doi: 10.3390/md22030132.

Abstract

The Verongida order comprises several sponge families, such as Aplysinellidae, Aplysinidae, Ianthellidae, and Pseudoceratinidae, reported for producing bromotyrosine-derived compounds. First identified in 1913, bromotyrosine derivatives have since captivated interest notably for their antitumor and antimicrobial properties. To date, over 360 bromotyrosine derivatives have been reported. Our review focuses specifically on bromotyrosine derivatives newly reported from 2004 to 2023, by summarizing current knowledge about their chemical diversity and their biological activities.

Keywords: Verongida; anticancer activities; antimicrobial activities; bromotyrosine derivatives; marine sponges.

Publication types

  • Review

MeSH terms

  • Animals
  • Bandages*
  • Humans
  • Porifera*
  • Tyrosine / analogs & derivatives*

Substances

  • bromotyrosine
  • Tyrosine

Grants and funding

This work was supported by the French government, through the UCAJEDI Investments in the Future project managed by the National Research Agency (ANR) with reference number ANR-15-IDEX-01. We thank the Canceropôle Provence-Alpes-Côte d’Azur and the Provence-Alpes-Côte d’Azur Region for the financial support provided to the MetaboCell and MetaboPure projects. P.F.M. is a recipient of a thesis grant from the “Ministère de l’enseignement supérieur de la recherche”. G.N.P. has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Curie grant agreement n°847581 (COFUND BoostUrCAreer program), from the Région SUD Provence-Alpes-Côte d’Azur and IDEX UCAjedi.