Structures and Biological Activities of Secondary Metabolites from Xylaria spp

Weikang Chen; Miao Yu; Shiji Chen; Tianmi Gong; Linlin Xie; Jinqin Liu; Chang Bian; Guolei Huang; Caijuan Zheng

doi:10.3390/jof10030190

Structures and Biological Activities of Secondary Metabolites from Xylaria spp

J Fungi (Basel). 2024 Feb 29;10(3):190. doi: 10.3390/jof10030190.

Authors

Weikang Chen^{1

2}, Miao Yu^{1

2}, Shiji Chen^{1

2}, Tianmi Gong^{1

2}, Linlin Xie^{1

2}, Jinqin Liu^{1

2}, Chang Bian^{1

2}, Guolei Huang^{1

2}, Caijuan Zheng^{1

2}

Affiliations

¹ Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
² Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou 571158, China.

Abstract

The fungus genus Xylaria is an important source of drug discoveries in scientific fields and in the pharmaceutical industry due to its potential to produce a variety of structured novel and bioactive secondary metabolites. This review prioritizes the structures of the secondary metabolites of Xylaria spp. from 1994 to January 2024 and their relevant biological activities. A total of 445 new compounds, including terpenoids, nitrogen-containing compounds, polyketides, lactones, and other classes, are presented in this review. Remarkably, among these compounds, 177 compounds show various biological activities, including cytotoxic, antimicrobial, anti-inflammatory, antifungal, immunosuppressive, and enzyme-inhibitory activities. This paper will guide further investigations into the structures of novel and potent active natural products derived from Xylaria and their potential contributions to the future development of new natural drug products in the agricultural and medicinal fields.

Keywords: Xylaria sp.; bioactivity; secondary metabolites.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundation of China (Nos. 32160108 and 2217702), the Key Research and Development Program of Hainan Province (No. ZDYF2024SHFZ116 and ZDYF2021SHFZ270), the Team Innovation Center for Academicians of Hainan Province, the Specific Research Fund for the Innovation Center of Hainan Province Academicians (No. YSPTZX202309), and the Key Science and Technology Program of Hainan Province (No. ZDKJ202008).