Trichothecenes with cytotoxic activity and benzene derivatives with hypolipidemic activity from trichothecium sp

Liang Xing; Yi-Fan Guo; Ke-Ran Hao; Yi-Ting Wu; An-An Yang

doi:10.1080/14786419.2024.2332488

Trichothecenes with cytotoxic activity and benzene derivatives with hypolipidemic activity from trichothecium sp

Nat Prod Res. 2024 Mar 27:1-7. doi: 10.1080/14786419.2024.2332488. Online ahead of print.

Authors

Liang Xing¹, Yi-Fan Guo^{1

2}, Ke-Ran Hao¹, Yi-Ting Wu¹, An-An Yang³

Affiliations

¹ Guangxi Key Laboratory of Urban Water Environment, College of chemistry and Environmental Engineering, Baise University, Baise, China.
² Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of chemistry & Pharmacy, Northwest A&F University, Shaanxi, China.
³ Hanzhong Key Research and Testing Laboratory for Edible Plant-source Jiaosu, Shaanxi Wuding Biotechnology Co., Ltd, Ninggiang, China.

PMID: 38534130
DOI: 10.1080/14786419.2024.2332488

Abstract

Five trichothecenes including a new one, together with two previously undescribed benzene derivatives were isolated from the solid culture of Trichothecium sp. Their structures were established by 1D and 2D NMR data in conjunction with HR-ESI-MS analysis. Compounds 1-5 exhibited cytotoxicity against MCF-7 cell lines at various levels ranging from IC₅₀ of 7.23 to 16.95 μM. Compound 6 decreased the concentration of blood lipids in zebra fish at the concentration of 20 μM.

Keywords: Trichothecium sp; cytotoxicity; hypolipidemic activity; trichothecene.