Role of differentiated embryo-chondrocyte expressed gene 2 in immunity

Yujing Li; Yinan Ma; Yang Liu; Na Tang; Wenzhu Zhang; Jingru Huo; Di Zhang

doi:10.3389/fimmu.2024.1335473

Role of differentiated embryo-chondrocyte expressed gene 2 in immunity

Front Immunol. 2024 Mar 12:15:1335473. doi: 10.3389/fimmu.2024.1335473. eCollection 2024.

Authors

Yujing Li^#^{1

2}, Yinan Ma^#^{1

2}, Yang Liu^#³, Na Tang^#^{1

2}, Wenzhu Zhang^#^{1

2}, Jingru Huo^#^{1

2}, Di Zhang^{1

2}

Affiliations

¹ Department of Pathology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
² Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China.
³ Department of Pathology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

^# Contributed equally.

Abstract

Differentiated embryo-chondrocyte expressed gene 2 (DEC2) is a member of the basic helix-loop-helix (bHLH) subfamily of transcription factors. DEC2 is implicated in tumor immunotherapy, immune system function regulation, and autoimmune diseases. DEC2 enhances Th2 cell differentiation by regulating the IL-2 and IL-4 signaling pathways and mediates the growth of B-1a cells, thereby promoting the occurrence and development of inflammatory responses. In this study, we review the reported roles of DEC2, including the regulation of immune cell differentiation and cytokine production in various cells in humans, and discuss its potential in treating autoimmune diseases and tumors.

Keywords: Bhlhe41; DEC1; DEC2; immune cells; immunity.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Autoimmune Diseases*
Basic Helix-Loop-Helix Transcription Factors* / metabolism
Chondrocytes / metabolism
Gene Expression
Humans
Transcription Factors / metabolism

Substances

Basic Helix-Loop-Helix Transcription Factors
Transcription Factors

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Natural Science Foundation of Liaoning Province (grant No. 2021-BS-106 to DZ), the National Natural Science Foundation of China (grant No. 81672302 to DZ, No. 81302312 to YL), General Project of Liaoning Provincial Education Department Foundation (grant No. LK201638 to DZ), the Natural Science Foundation of Liaoning Province (grant No. 20170540989 to YL), the Scientific Research Funds project of Education Department of Liaoning Province (grant no. JC2019027 to YL), the Scientific Research Funds project of Science and Technology Department of Sichuan Province (grant no. 21YYJC1616 to YL), and the Scientific Research Project of Sichuan Province (grant no. S2002 to YL).