Transmembrane protein 25 abrogates monomeric EGFR-driven STAT3 activation in triple-negative breast cancer

Chakrabhavi Dhananjaya Mohan; Kanchugarakoppal S Rangappa; Gautam Sethi

doi:10.1002/mco2.492

Transmembrane protein 25 abrogates monomeric EGFR-driven STAT3 activation in triple-negative breast cancer

MedComm (2020). 2024 Mar 26;5(4):e492. doi: 10.1002/mco2.492. eCollection 2024 Apr.

Authors

Chakrabhavi Dhananjaya Mohan¹, Kanchugarakoppal S Rangappa², Gautam Sethi³

Affiliations

¹ FEST Division CSIR-Indian Institute of Toxicology Research Lucknow Uttar Pradesh India.
² Institution of Excellence, Vijnana Bhavan University of Mysore Mysore Karnataka India.
³ Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore.

Abstract

In wild-type cells, TMEM25 physically associates with EGFR monomer and suppresses the EGFR-mediated STAT3 phosphorylation, which results in the sequestration of unphosphorylated STAT3 in the cytoplasm. In TMEM^-/- cells, EGFR monomer phosphorylates STAT3 at the basal level.