Genome-Wide CRISPR Screen Identifies Phospholipid Scramblase 3 as the Biological Target of Mitoprotective Drug SS-31

Affiliations

• ¹ Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
• ² Department of Genetics, Genomics, and Informatics; College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee.
• ³ Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.
• ⁴ Department of Medicine, University of Alabama, Birmingham, Alabama.
• ⁵ Division of Nephrology, Department of Medicine, The Ohio State University, Columbus, Ohio.
• ⁶ Department of Surgery, College of Medicine, Transplant Research Institute, The University of Tennessee Health Science Center, Memphis, Tennessee.
• ⁷ Department of Pediatrics, The Ohio State University College of Medicine and Kidney and Urinary Tract Research Center, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
• ⁸ Division of Renal and Transplant Pathology, Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio.
• ⁹ Social Profit Network Research Lab, Menlo Park, California.
• ¹⁰ Department of Microbiology, Immunology, and Biochemistry; College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee.