Isoform- and cell-state-specific APOE homeostasis and function

Karina Lindner; Anne-Claude Gavin

doi:10.4103/NRR.NRR-D-23-01470

Isoform- and cell-state-specific APOE homeostasis and function

Neural Regen Res. 2024 Nov 1;19(11):2456-2466. doi: 10.4103/NRR.NRR-D-23-01470. Epub 2024 Jan 31.

Authors

Karina Lindner^{1

2}, Anne-Claude Gavin^{1

2}

Affiliations

¹ Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
² Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

PMID: 38526282
DOI: 10.4103/NRR.NRR-D-23-01470

Abstract

Apolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic coupling. It ensures the survival of neurons under stressful conditions and hyperactivity by nourishing and detoxifying them. Apolipoprotein E polymorphism, combined with environmental stresses and/or age-related alterations, influences the risk of developing late-onset Alzheimer's disease. In this review, we discuss our current knowledge of how apolipoprotein E homeostasis, i.e. its synthesis, secretion, degradation, and lipidation, is affected in Alzheimer's disease.