Yeast cell wall mannan structural features, biological activities, and production strategies

Kwang-Rim Baek; Sudha Rani Ramakrishnan; Soo-Jung Kim; Seung-Oh Seo

doi:10.1016/j.heliyon.2024.e27896

Yeast cell wall mannan structural features, biological activities, and production strategies

Heliyon. 2024 Mar 8;10(6):e27896. doi: 10.1016/j.heliyon.2024.e27896. eCollection 2024 Mar 30.

Authors

Kwang-Rim Baek¹, Sudha Rani Ramakrishnan^{2

3}, Soo-Jung Kim², Seung-Oh Seo^{1

4}

Affiliations

¹ Department of Food Science and Biotechnology, Seoul National University of Science and Technology, Seoul, 01811, Republic of Korea.
² Department of Integrative Food, Bioscience, and Biotechnology, and Research Center for Biological Cybernetics, Chonnam National University, Gwangju, 61186, Republic of Korea.
³ Department of Biotechnology, Anna University, Chennai, 600025, India.
⁴ Research Institute of Food and Biotechnology, Seoul, 01811, Republic of Korea.

Abstract

Mannan and outer structural yeast cell wall polysaccharides have recently garnered attention for their health defense and cosmetic applications. In addition, many studies have confirmed that yeast cell wall mannans exhibit various biological activities, such as antioxidant, immune regulation, reducing hyperlipidemia, and gut health promotion. This paper elucidates yeast cell wall mannan structural features, biological activities, underlying molecular mechanisms, and biosynthesis. Moreover, mannan-overproducing strategies through yeast strain engineering are emphasized and discussed. This review will provide a scientific basis for yeast cell wall mannan research and industrial applications.

Keywords: Biological activities; Engineering; Mannan; Overproduction; Yeast.

Publication types

Review