Growth and differentiation factor-15: A link between inflammaging and cardiovascular disease

Balázs Bence Nyárády; Loretta Zsuzsa Kiss; Zsolt Bagyura; Béla Merkely; Edit Dósa; Orsolya Láng; László Kőhidai; Éva Pállinger

doi:10.1016/j.biopha.2024.116475

Growth and differentiation factor-15: A link between inflammaging and cardiovascular disease

Biomed Pharmacother. 2024 May:174:116475. doi: 10.1016/j.biopha.2024.116475. Epub 2024 Mar 24.

Authors

Balázs Bence Nyárády¹, Loretta Zsuzsa Kiss², Zsolt Bagyura³, Béla Merkely⁴, Edit Dósa⁵, Orsolya Láng⁶, László Kőhidai⁷, Éva Pállinger⁸

Affiliations

¹ Heart and Vascular Center, Semmelweis University, Városmajor utca 68, Budapest H-1122, Hungary. Electronic address: nyarady.balazs.bence@semmelweis.hu.
² Heart and Vascular Center, Semmelweis University, Városmajor utca 68, Budapest H-1122, Hungary. Electronic address: kiss.loretta.zsuzsa@semmelweis.hu.
³ Heart and Vascular Center, Semmelweis University, Városmajor utca 68, Budapest H-1122, Hungary. Electronic address: bagyura.zsolt@semmelweis.hu.
⁴ Heart and Vascular Center, Semmelweis University, Városmajor utca 68, Budapest H-1122, Hungary. Electronic address: titkarsag@kardio.sote.hu.
⁵ Heart and Vascular Center, Semmelweis University, Városmajor utca 68, Budapest H-1122, Hungary. Electronic address: dosa.edit@semmelweis.hu.
⁶ Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, Budapest H-1089, Hungary. Electronic address: lang.orsolya@med.semmelweis-univ.hu.
⁷ Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, Budapest H-1089, Hungary. Electronic address: kohidai.laszlo@semmelweis.hu.
⁸ Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, Budapest H-1089, Hungary. Electronic address: pallinger.eva@semmelweis.hu.

PMID: 38522236
DOI: 10.1016/j.biopha.2024.116475

Abstract

Age-related disorders are closely linked to the accumulation of senescent cells. The senescence-associated secretory phenotype (SASP) sustains and progresses chronic inflammation, which is involved in cellular and tissue dysfunction. SASP-related growth and differentiation factor-15 (GDF-15) is an immunoregulatory cytokine that is coupled to aging and thus may have a regulatory role in the development and maintenance of atherosclerosis, a major cause of cardiovascular disease (CVD). Although the effects of GDF-15 are tissue-specific and dependent on microenvironmental changes such as inflammation, available data suggest that GDF-15 has a significant role in CVD. Thus, GDF-15 is a promising biomarker and potential therapeutic target for atherosclerotic CVD.

Keywords: Aging; Cardiovascular disease; Growth and differentiation factor-15; Inflammaging; Vascular inflammation.

Publication types

Review

MeSH terms

Aging* / metabolism
Animals
Atherosclerosis / immunology
Atherosclerosis / metabolism
Biomarkers / metabolism
Cardiovascular Diseases* / metabolism
Cellular Senescence
Growth Differentiation Factor 15* / metabolism
Humans
Inflammation* / metabolism
Inflammation* / pathology
Senescence-Associated Secretory Phenotype

Substances

Growth Differentiation Factor 15
Biomarkers
GDF15 protein, human