Carbon quantum dots of ginsenoside Rb1 for application in a mouse model of intracerebral Hemorrhage

Xiaolong Tang; Xinyu Yang; Yamei Yu; Miaojing Wu; Yuanyuan Li; Zhe Zhang; Guangyu Jia; Qi Wang; Wei Tu; Ye Wang; Xingen Zhu; Shiyong Li

doi:10.1186/s12951-024-02368-w

Carbon quantum dots of ginsenoside Rb1 for application in a mouse model of intracerebral Hemorrhage

J Nanobiotechnology. 2024 Mar 22;22(1):125. doi: 10.1186/s12951-024-02368-w.

Authors

Xiaolong Tang^#^{1

2}, Xinyu Yang^#^{1

2}, Yamei Yu^#^{1

3}, Miaojing Wu^#^{1

2}, Yuanyuan Li¹, Zhe Zhang^{1

2}, Guangyu Jia^{1

2}, Qi Wang^{1

2}, Wei Tu^{4

5}, Ye Wang^{6

7}, Xingen Zhu^{8

9}, Shiyong Li^{10

11}

Affiliations

¹ Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
² Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi, 330036, China.
³ Department of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
⁴ Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China. Ndefy06044@ncu.edu.cn.
⁵ Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi, 330036, China. Ndefy06044@ncu.edu.cn.
⁶ Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China. ndefy08041@ncu.edu.cn.
⁷ Department of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China. ndefy08041@ncu.edu.cn.
⁸ Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China. ndefy89006@ncu.edu.cn.
⁹ Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi, 330036, China. ndefy89006@ncu.edu.cn.
¹⁰ Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China. sylicg@ncu.edu.cn.
¹¹ Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi, 330036, China. sylicg@ncu.edu.cn.

^# Contributed equally.

Abstract

After intracerebral hemorrhage (ICH) occurs, the overproduction of reactive oxygen species (ROS) and iron ion overload are the leading causes of secondary damage. Removing excess iron ions and ROS in the meningeal system can effectively alleviate the secondary damage after ICH. This study synthesized ginsenoside Rb1 carbon quantum dots (RBCQDs) using ginsenoside Rb1 and ethylenediamine via a hydrothermal method. RBCQDs exhibit potent capabilities in scavenging ABTS + free radicals and iron ions in solution. After intrathecal injection, the distribution of RBCQDs is predominantly localized in the subarachnoid space. RBCQDs can eliminate ROS and chelate iron ions within the meningeal system. Treatment with RBCQDs significantly improves blood flow in the meningeal system, effectively protecting dying neurons, improving neurological function, and providing a new therapeutic approach for the clinical treatment of ICH.

Keywords: Carbon quantum dots; Ginsenoside Rb1; Oxidative stress; Reactive oxygen species; iron overload.

MeSH terms

Animals
Cerebral Hemorrhage / drug therapy
Ginsenosides*
Ions
Iron
Mice
Quantum Dots*
Reactive Oxygen Species

Substances

ginsenoside Rb1
Reactive Oxygen Species
Iron
Ions
Ginsenosides

Abstract

MeSH terms

Substances

Grants and funding