Chronic hepatitis B virus (HBV) infection will greatly contribute to raising the occurrence probability of cirrhosis and hepatocellular carcinoma in patients. Although existing antiviral treatment regimens have a certain effect on delaying disease progression and improving prognosis, it is still not effective in attaining functional cures. Hepatitis B virus DNA integration may be one of the reasons for this phenomenon. Therefore, this paper reviews the possible mechanisms of HBV DNA integration in maintaining chronic inflammation of the liver, evading existing antiviral treatment methods, and inducing hepatocellular carcinoma so as to further deepen the understanding of the role of HBV DNA integration in the occurrence and development of chronic hepatitis B, providing ideas and references for formulating better treatment strategies.
乙型肝炎病毒（HBV）慢性感染会导致患者发生肝硬化、肝细胞癌的概率大大增加。现有的抗病毒治疗方案虽然对延缓病情进展，改善预后有一定的作用，但仍不能有效地达到功能性治愈。整合HBV DNA可能是造成该现象的原因之一。因此，现就整合HBV DNA在维持肝脏慢性炎症，逃避现有的抗病毒治疗手段并且诱导肝细胞癌的可能作用机制进行综述，进一步加深对整合HBV DNA在慢性乙型肝炎发生和发展中作用的认识，为制定更优治疗策略提供思路和参考。.
Keywords: Chronic hepatitis B virus infection; Functional cure; Hepatitis B virus; Integrated HBV DNA; Viral replication.