Zinc unbound concentration as an anchor to drive individualize repletion

D Metsu; C Cinq-Frais; C Camare; S Caspar-Bauguil; A Galinier

doi:10.1016/j.clnu.2024.02.010

Zinc unbound concentration as an anchor to drive individualize repletion

Clin Nutr. 2024 Apr;43(4):1021-1023. doi: 10.1016/j.clnu.2024.02.010. Epub 2024 Feb 12.

Authors

D Metsu¹, C Cinq-Frais², C Camare³, S Caspar-Bauguil⁴, A Galinier⁵

Affiliations

¹ Department of Clinical Laboratory, Montauban Hospital, Montauban, France; Institute of Metabolic and Cardiovascular Diseases (I2MC), Equipe MetaDiab, University of Toulouse, INSERM, University of Toulouse III - Paul Sabatier (UPS), Toulouse, France. Electronic address: d.metsu@ch-montauban.fr.
² Department of Biochemistry, Toulouse University Hospital, Toulouse, France.
³ Department of Biochemistry, Toulouse University Hospital, Toulouse, France; Institute for Metabolic and Cardiovascular Diseases (I2MC), UMR 1297, INSERM, University of Toulouse III - Paul Sabatier (UPS), 31432 Toulouse, France.
⁴ Institute of Metabolic and Cardiovascular Diseases (I2MC), Equipe MetaDiab, University of Toulouse, INSERM, University of Toulouse III - Paul Sabatier (UPS), Toulouse, France; Department of Biochemistry, Toulouse University Hospital, Toulouse, France.
⁵ Department of Biochemistry, Toulouse University Hospital, Toulouse, France; Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Université Paul Sabatier, Toulouse, France.

PMID: 38513551
DOI: 10.1016/j.clnu.2024.02.010

Abstract

Background and aims: Zinc (Zn) quantification is of particular interest in many clinical condition (e.g. inflammatory disease, critical care). Currently, Zn status is assessed by measuring plasma/serum concentration. This concentration corresponds to the sum of unbound Zn (Zn-C_u) and Zn highly bound to albumin (Zn-C_b).

Methods: Using a pharmacokinetic approach to the interpretation of total Zn concentration (Zn-C_t), taking into account Zn-C_u and the influence of hypoalbuminemia on Zn-C_b, it is possible to improve the individualization of Zn repletion.

Results: Therefore, during pregnancy and in certain inflammatory disease situations, repletion may not be necessary. However, as in critical care, it would be more appropriate to perform Zn-C_u assays to improve Zn repletion.

Conclusion: Coupled total and unbound Zn should be monitored in order to individualize Zn repletion.

Keywords: Albumin; Repletion; Unbound concentration; Zinc.

MeSH terms

Copper*
Female
Humans
Pregnancy
Zinc* / metabolism

Substances

Zinc
Copper