Updates on brain regions and neuronal circuits of movement disorders in Parkinson's disease

Juan Wang; Xiaoting Wang; Hui Li; Limin Shi; Ning Song; Junxia Xie

doi:10.1016/j.arr.2023.102097

Updates on brain regions and neuronal circuits of movement disorders in Parkinson's disease

Ageing Res Rev. 2023 Dec:92:102097. doi: 10.1016/j.arr.2023.102097. Epub 2023 Oct 28.

Authors

Juan Wang¹, Xiaoting Wang¹, Hui Li¹, Limin Shi¹, Ning Song², Junxia Xie³

Affiliations

¹ Institute of Brain Science and Disease, School of Basic Medicine, Qingdao University, Qingdao, Shandong, China; Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Qingdao University, Qingdao, Shandong, China; Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, Shandong, China.
² Institute of Brain Science and Disease, School of Basic Medicine, Qingdao University, Qingdao, Shandong, China; Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Qingdao University, Qingdao, Shandong, China; Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, Shandong, China. Electronic address: ningsong@qdu.edu.cn.
³ Institute of Brain Science and Disease, School of Basic Medicine, Qingdao University, Qingdao, Shandong, China; Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Qingdao University, Qingdao, Shandong, China; Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, Shandong, China. Electronic address: jxiaxie@public.qd.sd.cn.

PMID: 38511877
DOI: 10.1016/j.arr.2023.102097

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disease with a global burden that affects more often in the elderly. The basal ganglia (BG) is believed to account for movement disorders in PD. More recently, new findings in the original regions in BG involved in motor control, as well as the new circuits or new nucleuses previously not specifically considered were explored. In the present review, we provide up-to-date information related to movement disorders and modulations in PD, especially from the perspectives of brain regions and neuronal circuits. Meanwhile, there are updates in deep brain stimulation (DBS) and other factors for the motor improvement in PD. Comprehensive understandings of brain regions and neuronal circuits involved in motor control could benefit the development of novel therapeutical strategies in PD.

Keywords: Basal ganglia; Deep brain stimulation; Motor symptoms; Neuronal circuits; Parkinson’s disease.

Publication types

Review

MeSH terms

Aged
Basal Ganglia
Brain
Deep Brain Stimulation*
Humans
Neurodegenerative Diseases*
Parkinson Disease* / therapy