No evidence for association between rs10191329 severity locus and longitudinal disease severity in 1813 relapse-onset multiple sclerosis patients from the MSBase registry

Maria Pia Campagna; Eva Kubala Havrdova; Dana Horakova; Guillermo Izquierdo; Fuencisla Matesanz; Sara Eichau; Jeannette Lechner-Scott; Bruce V Taylor; Maria-Isabel García-Sanchéz; Antonio Alcina; Anneke van der Walt; Helmut Butzkueven; Vilija G Jokubaitis

doi:10.1177/13524585241240406

No evidence for association between rs10191329 severity locus and longitudinal disease severity in 1813 relapse-onset multiple sclerosis patients from the MSBase registry

Mult Scler. 2024 Mar 21:13524585241240406. doi: 10.1177/13524585241240406. Online ahead of print.

Authors

Maria Pia Campagna¹, Eva Kubala Havrdova², Dana Horakova², Guillermo Izquierdo³, Fuencisla Matesanz⁴, Sara Eichau³, Jeannette Lechner-Scott^{5

6}, Bruce V Taylor⁷, Maria-Isabel García-Sanchéz⁸, Antonio Alcina⁴, Anneke van der Walt^{1

9}, Helmut Butzkueven^{1

9}, Vilija G Jokubaitis^{1

9}

Affiliations

¹ Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
² Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
³ Hospital Universitario Virgen Macarena, Sevilla, Spain.
⁴ Instituto de Parasitología y Biomedicina López Neyra, CSIC, Granada, Spain.
⁵ Department of Neurology, John Hunter Hospital, Newcastle, NSW, Australia.
⁶ School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW, Australia.
⁷ Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.
⁸ UGC Neurología, Hospital Universitario Virgen Macarena, Nodo Biobanco del Sistema Sanitario Público de Andalucía, Sevilla, Spain.
⁹ Department of Neurology, Alfred Health, Melbourne, VIC, Australia.

PMID: 38511853
DOI: 10.1177/13524585241240406

Abstract

Background: The International Multiple Sclerosis Genetics Consortium and MultipleMS Consortium recently reported a genetic variant associated with multiple sclerosis (MS) severity. However, it remains unclear if these variants remain associated with more robust, longitudinal measures of disease severity.

Methods: We examined the top variant, rs10191329, from Harroud et al.'s study in 1813 relapse-onset MS patients from the MSBase Registry to assess association with longitudinal disease severity.

Results: Our analysis revealed no significant association between rs10191329 genotype and longitudinal binary disease severity (p > 0.05).

Conclusion: These findings highlight the complexity of genetic factors mediating long-term MS outcomes and the need for further research.

Keywords: Multiple sclerosis; disease severity; genetics.