Current progress toward isogeometric modeling of the heart biophysics

Michele Torre; Simone Morganti; Francesco S Pasqualini; Alessandro Reali

doi:10.1063/5.0152690

Current progress toward isogeometric modeling of the heart biophysics

Biophys Rev (Melville). 2023 Nov 13;4(4):041301. doi: 10.1063/5.0152690. eCollection 2023 Dec.

Authors

Michele Torre¹, Simone Morganti², Francesco S Pasqualini¹, Alessandro Reali¹

Affiliations

¹ Department of Civil Engineering and Architecture, University of Pavia, Via Ferrata 3, 27100 Pavia, Italy.
² Department of Electrical, Computer, and Biomedical Engineering, University of Pavia, Via Ferrata 5, 27100 Pavia, Italy.

PMID: 38510845
PMCID: PMC10903424 (available on 2024-11-13)
DOI: 10.1063/5.0152690

Abstract

In this paper, we review a powerful methodology to solve complex numerical simulations, known as isogeometric analysis, with a focus on applications to the biophysical modeling of the heart. We focus on the hemodynamics, modeling of the valves, cardiac tissue mechanics, and on the simulation of medical devices and treatments. For every topic, we provide an overview of the methods employed to solve the specific numerical issue entailed by the simulation. We try to cover the complete process, starting from the creation of the geometrical model up to the analysis and post-processing, highlighting the advantages and disadvantages of the methodology.

Publication types

Review