Cortical microstructural involvement in cerebral small vessel disease

Annemarie Reiländer; Marlene Engel; Ulrike Nöth; Ralf Deichmann; Manoj Shrestha; Marlies Wagner; René-Maxime Gracien; Alexander Seiler

doi:10.1016/j.cccb.2024.100218

Cortical microstructural involvement in cerebral small vessel disease

Cereb Circ Cogn Behav. 2024 Mar 11:6:100218. doi: 10.1016/j.cccb.2024.100218. eCollection 2024.

Authors

Annemarie Reiländer^{1

2}, Marlene Engel¹, Ulrike Nöth², Ralf Deichmann², Manoj Shrestha², Marlies Wagner^{2

3}, René-Maxime Gracien^{1

2}, Alexander Seiler^{2

4

5}

Affiliations

¹ Department of Neurology, Goethe University Hospital, Frankfurt, Germany.
² Brain Imaging Center, Goethe University, Frankfurt, Germany.
³ Institute of Neuroradiology, Goethe University Hospital, Frankfurt, Germany.
⁴ Department of Neurology, University Hospital Schleswig-Holstein, Kiel, Germany.
⁵ Neurovascular Center, University Hospital Schleswig-Holstein, Kiel, Germany.

Abstract

Background: In cerebral small vessel disease (CSVD), cortical atrophy occurs at a later stage compared to microstructural abnormalities and therefore cannot be used for monitoring short-term disease progression. We aimed to investigate whether cortical diffusion tensor imaging (DTI) and quantitative (q) magnetic resonance imaging (MRI) are able to detect early microstructural involvement of the cerebral cortex in CSVD.

Materials and methods: 33 CSVD patients without significant cortical or whole-brain atrophy and 16 healthy control subjects were included and underwent structural MRI, DTI and high-resolution qMRI with T₂, T₂* and T_2' mapping at 3 T as well as comprehensive cognitive assessment. After tissue segmentation and reconstruction of the cortical boundaries with the Freesurfer software, DTI and qMRI parameters were saved as surface datasets and averaged across all vertices.

Results: Cortical diffusivity and quantitative T₂ values were significantly increased in patients compared to controls (p < 0.05). T₂ values correlated significantly positively with white matter hyperintensity (WMH) volume (p < 0.01). Both cortical diffusivity and T₂ showed significant negative associations with axonal damage to the white matter fiber tracts (p < 0.05).

Conclusions: Cortical diffusivity and quantitative T₂ mapping are suitable to detect microstructural involvement of the cerebral cortex in CSVD and represent promising imaging biomarkers for monitoring disease progression and effects of therapeutical interventions in clinical studies.

Keywords: Brain atrophy; Cortical microstructure; Diffusion tensor imaging; Microstructural impairment; Small vessel disease; quantitative MRI.