Impact of mHealth application on adherence to cardiac rehabilitation guidelines after a coronary event: Randomised controlled clinical trial protocol

Celia Cruz-Cobo; María Ángeles Bernal-Jiménez; Germán Calle-Pérez; Livia Gheorghe; Alejandro Gutiérrez-Barrios; Dolores Cañadas-Pruaño; Amelia Rodríguez-Martín; Josep A Tur; Rafael Vázquez-García; María José Santi-Cano

doi:10.1177/20552076241234474

Impact of mHealth application on adherence to cardiac rehabilitation guidelines after a coronary event: Randomised controlled clinical trial protocol

Digit Health. 2024 Mar 19:10:20552076241234474. doi: 10.1177/20552076241234474. eCollection 2024 Jan-Dec.

Authors

Celia Cruz-Cobo^{1

2

3}, María Ángeles Bernal-Jiménez^{1

2

3}, Germán Calle-Pérez^{2

4}, Livia Gheorghe^{2

4}, Alejandro Gutiérrez-Barrios^{2

4}, Dolores Cañadas-Pruaño^{2

4}, Amelia Rodríguez-Martín^{1

5}, Josep A Tur⁶, Rafael Vázquez-García^{2

4}, María José Santi-Cano^{1

2

3}

Affiliations

¹ Faculty of Nursing and Physiotherapy, University of Cádiz, Cádiz, Spain.
² Institute of Biomedical Research and Innovation of Cádiz (INiBICA), Cádiz, Spain.
³ Research Group on Nutrition, Molecular, Pathophysiological and Social Issues, University of Cádiz, Cádiz, Spain.
⁴ Clinical Cardiology Unit, Puerta del Mar Hospital, Cádiz, Spain.
⁵ Biomedicine, Biotechnology, and Public Health Department, University of Cadiz, Cádiz, Spain.
⁶ Research Group on Community Nutrition & Oxidative Stress, University of the Balearic Islands-IUNICS, IDISBA & CIBEROBN, Palma de Mallorca, Spain.

Abstract

Background: Coronary disease is the main cause of death around the world. mHealth technology is considered attractive and promising to promote behavioural changes aimed at healthy lifestyle habits among coronary patients. The purpose of this study is to evaluate the efficacy of an mHealth intervention regarding improved results in secondary prevention in patients after an acute myocardial infarction (AMI) or angina in terms of lifestyle, clinical variables and therapeutic compliance.

Methods: Randomised clinical trial with 300 patients who underwent a percutaneous coronary intervention (PCI) with stent implant. They will be assigned to either the mHealth group, subject to a self-monitored educational intervention involving an internet application installed on their mobile phone or tablet, or to a control group receiving standard healthcare (150 patients in each arm). The primary outcome variables will be adherence to the Mediterranean diet, physical activity, smoking, therapeutic compliance, knowledge acquired, user-friendliness and satisfaction with the application. Measurements of blood pressure, heart rate, body weight, waist circumference (WC) and the 6-min walk test will be taken. Furthermore, the blood lipid profile, glucose and HbA1c will be evaluated. Clinical interview will be conducted, and validated questionnaires completed. The primary quantitative results will be compared using an analysis of covariance adjusted for age and sex. A multivariate analysis will be performed to examine the association of the intervention with lifestyle habits, the control of cardiovascular risk factors (CDRFs) and the results after the hospital discharge (major adverse events, treatment compliance and lifestyle).

Conclusions: The study will provide evidence about the effectiveness of an mHealth intervention at improving the lifestyle of the participants and could be offered to patients with coronary disease to complement existing services.

Trial registration: NCT05247606. [https://ClinicalTrials.gov]. 21/02/2022.

Keywords: Coronary event; coronary heart disease; eHealth; lifestyle; mHealth.

Associated data

ClinicalTrials.gov/NCT05247606