Assessing the diversity and determinants of health-related quality of life measures in patients with acute heart failure

Dhrumil Patil; Hsin-Ju Tang; Fang-Hsiu Kuo; Han Siong Toh; I-Ning Yang; Wei-Ting Chang; Mei-Chuan Lee; Kai-Ning Chung; Chi-Ya Huang; Wan-Hsuan Hsu; Ting-Chia Chang; Jhih-Yuan Shih; Chia-Te Liao

doi:10.1002/ehf2.14745

Assessing the diversity and determinants of health-related quality of life measures in patients with acute heart failure

ESC Heart Fail. 2024 Mar 20. doi: 10.1002/ehf2.14745. Online ahead of print.

Authors

Dhrumil Patil^{1

2}, Hsin-Ju Tang³, Fang-Hsiu Kuo⁴, Han Siong Toh^{5

6

7}, I-Ning Yang^{8

9}, Wei-Ting Chang⁴, Mei-Chuan Lee^{10

11

12}, Kai-Ning Chung⁴, Chi-Ya Huang⁸, Wan-Hsuan Hsu¹³, Ting-Chia Chang¹⁴, Jhih-Yuan Shih^{4

7}, Chia-Te Liao¹⁵

Affiliations

¹ Baroda Medical College, Vadodara, India.
² World Youth Heart Federation, Vadodara, India.
³ Department of Nursing, Chang Gung University of Science and Technology, Chronic Diseases and Health Promotion Research Center, Chiayi, Taiwan.
⁴ Division of Cardiology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
⁵ Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan, Taiwan.
⁶ Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁷ Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
⁸ Division of Nephrology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
⁹ Institute of Clinical Pharmacy and Pharmaceutical Sciences, National Cheng Kung University, Tainan, Taiwan.
¹⁰ Department of Pharmacy, Chi Mei Medical Center, Tainan, Taiwan.
¹¹ Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
¹² Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
¹³ Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
¹⁴ Division of Chest Medicine, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
¹⁵ Division of Cardiovascular Medicine, Chi Mei Medical Center, School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.

PMID: 38509031
DOI: 10.1002/ehf2.14745

Abstract

Aims: Heart failure with reduced ejection fraction (HFrEF) significantly impacts health-related quality of life (HR-QoL). Existing HR-QoL questionnaires can show inconsistencies, potentially misrepresenting patient self-reports. This study examines the variation in HR-QoL measurement tools for HFrEF patients, identifying related determinants.

Methods and results: We retrospectively analysed 134 hospitalized patients with acute decompensated HFrEF at a Taiwanese tertiary centre's Heart Failure Post-Acute-Care (HF-PAC) programme. Participants completed the EuroQol-5 dimension (EQ-5D) questionnaire, the EQ-5D visual analogue scale (VAS), and the Minnesota Living with Heart Failure Questionnaire (MLHFQ). Utility values were obtained from the EQ-5D questionnaire. Demographic features were depicted using descriptive statistics, while multivariate regression was used to ascertain relationships between HR-QoL measurements and determinants. Average scores for EQ-5D, MLHFQ, EQ-5D utility, and VAS were 6.1 ± 1.6, 21.8 ± 21.3, 81.7 ± 27.0, and 59.5 ± 14.6, respectively. Significant correlations were observed among the three tools. The New York Heart Association functional class showed a notable association with all tool scores. Other associations encompassed EQ-5D with coronary artery disease, mineralocorticoid receptor antagonists, and the 6 min walk test; EQ-5D VAS with chronic kidney disease; and MLHFQ with age.

Conclusions: This study illuminates the variance in HR-QoL measurement tools for Taiwanese HFrEF patients. Using a range of these tools is beneficial in unveiling diverse determinants and approaching comprehensive patient-centred care. However, for a more precise HR-QoL assessment in Taiwanese HFrEF patients, recalibrating the EQ-5D-derived utility scores might be necessary, emphasizing the importance of patient-specific considerations within the HF-PAC programme.

Keywords: HFrEF; Heart failure; Patient‐reported outcome; Quality of life; Questionnaire.

Grants and funding

Chi Mei Medical Center