Direct Quantification of Gadolinium Retention in Young Patients by ICP-MS Analysis of Extracted Teeth

Laura S O'Donohue; Matthew H Friedland; Prasad R Shankar; Carlos Gonzalez-Cabezas; Susan E Flannagan; Sharon Aronovich; Maria Masotti; Russell E Bornschein; Matthew S Davenport

doi:10.2214/AJR.24.30927

Direct Quantification of Gadolinium Retention in Young Patients by ICP-MS Analysis of Extracted Teeth

AJR Am J Roentgenol. 2024 Mar 20. doi: 10.2214/AJR.24.30927. Online ahead of print.

Authors

Laura S O'Donohue¹, Matthew H Friedland², Prasad R Shankar^{1

3}, Carlos Gonzalez-Cabezas⁴, Susan E Flannagan⁴, Sharon Aronovich⁵, Maria Masotti⁶, Russell E Bornschein⁷, Matthew S Davenport⁸

Affiliations

¹ Department of Radiology, Michigan Medicine, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109.
² University of Michigan Medical School, 1301 Catherine St, Ann Arbor, MI, 48109.
³ Imaging Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44194.
⁴ School of Dentistry, University of Michigan, 1011 N. University Ave, Ann Arbor, MI, 48109.
⁵ Department of Oral and Maxillofacial Surgery, Michigan Medicine, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109.
⁶ School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109.
⁷ Department of Chemistry, University of Michigan, 930 N. University Ave, Ann Arbor, MI, 48103.
⁸ Department of Radiology and Department of Urology, Michigan Medicine, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109.

PMID: 38506538
DOI: 10.2214/AJR.24.30927

No abstract available

Plain language summary

In this 10-patient prospective pilot study, we show feasibility of pragmatic, direct ex vivo measurement of gadolinium retention from group II gadolinium-based contrast agents (GBCAs) in young patients following routine tooth extraction. This noninvasive method may support future research attempting to understand the link between GBCA exposure and clinical outcomes.