Puzzling phenomenon: adult-onset cancer predisposition and pediatric cancer

Michaela Kuhlen; Thomas G Hofmann; Monika M Golas

doi:10.1016/j.trecan.2024.02.011

Puzzling phenomenon: adult-onset cancer predisposition and pediatric cancer

Trends Cancer. 2024 Mar 18:S2405-8033(24)00049-9. doi: 10.1016/j.trecan.2024.02.011. Online ahead of print.

Authors

Michaela Kuhlen¹, Thomas G Hofmann², Monika M Golas³

Affiliations

¹ Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany. Electronic address: michaela.kuhlen@uk-augsburg.de.
² Institute of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
³ Human Genetics, Faculty of Medicine, University of Augsburg, Augsburg, Germany.

PMID: 38503638
DOI: 10.1016/j.trecan.2024.02.011

Abstract

Pathogenic variants (PVs) in DNA repair-linked adult-onset cancer predisposition genes, including double heterozygosity, are increasingly identified in pediatric patients with cancer. Their role in childhood cancer, however, remains poorly understood. Integrating comprehensive tumor analysis is integral for understanding the contribution of such PVs in cancer development and personalized cancer care.

Keywords: DNA repair; adult-onset; cancer; children; double heterozygosity; germline variants.