Advances in targeted therapy and biomarker research in thyroid cancer

Front Endocrinol (Lausanne). 2024 Mar 4:15:1372553. doi: 10.3389/fendo.2024.1372553. eCollection 2024.

Abstract

Driven by the intricacy of the illness and the need for individualized treatments, targeted therapy and biomarker research in thyroid cancer represent an important frontier in oncology. The variety of genetic changes associated with thyroid cancer demand more investigation to elucidate molecular details. This research is clinically significant since it can be used to develop customized treatment plans. A more focused approach is provided by targeted therapies, which target certain molecular targets such as mutant BRAF or RET proteins. This strategy minimizes collateral harm to healthy tissues and may also reduce adverse effects. Simultaneously, patient categorization based on molecular profiles is made possible by biomarker exploration, which allows for customized therapy regimens and maximizes therapeutic results. The benefits of targeted therapy and biomarker research go beyond their immediate clinical impact to encompass the whole cancer landscape. Comprehending the genetic underpinnings of thyroid cancer facilitates the creation of novel treatments that specifically target aberrant molecules. This advances the treatment of thyroid cancer and advances precision medicine, paving the way for the treatment of other cancers. Taken simply, more study on thyroid cancer is promising for better patient care. The concepts discovered during this investigation have the potential to completely transform the way that care is provided, bringing in a new era of personalized, precision medicine. This paradigm shift could improve the prognosis and quality of life for individuals with thyroid cancer and act as an inspiration for advances in other cancer types.

Keywords: biomarker research; clinical application; disease treatment; targeted therapy; thyroid cancer.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism
  • Humans
  • Precision Medicine
  • Prognosis
  • Quality of Life*
  • Thyroid Neoplasms* / drug therapy
  • Thyroid Neoplasms* / genetics

Substances

  • Biomarkers, Tumor

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The work was supported by the National Natural Science Foundation of China (No. 82305046, 82304902), the Natural Science Foundation of Jiangsu Province (No. BK20220467), the Major Project of the Natural Science Research of Jiangsu Higher Education Institutions (No.22KJB310013), Jiangsu Provincial Double-Innovation Doctor Program (No. JSSCBS20220452, JSSCBS20220472), Young Elite Scientists Sponsorship Program by CACM (2022-QNRC2-B15), Outstanding Young Doctoral Training Program (2023QB0124).