Mechanism and treatment of diarrhea associated with tyrosine kinase inhibitors

Jiangnan Liu; Shuai Yan; Juntong Du; Lizhi Teng; Ru Yang; Peng Xu; Weiyang Tao

doi:10.1016/j.heliyon.2024.e27531

Mechanism and treatment of diarrhea associated with tyrosine kinase inhibitors

Heliyon. 2024 Mar 6;10(6):e27531. doi: 10.1016/j.heliyon.2024.e27531. eCollection 2024 Mar 30.

Authors

Jiangnan Liu^{1

2

3}, Shuai Yan^{1

2

4

3}, Juntong Du^{1

2

3}, Lizhi Teng^{1

2

3}, Ru Yang^{1

2

3}, Peng Xu^{1

2

3}, Weiyang Tao^{1

2

4

3}

Affiliations

¹ Department of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, Heilongjiang, 150001, PR China.
² Key Laboratory of Acoustic, Optical and Electromagnetic Diagnosis and Treatment of Cardiovascular Diseases, Heilongjiang, 150001, PR China.
³ The Cell Transplantation Key Laboratory of National Health Commission, Heilongjiang, 150001, PR China.
⁴ Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, Heilongjiang, 150001, PR China.

Abstract

Tyrosine kinase inhibitors (TKIs) have become first-line drugs for cancer treatment. However, their clinical use is seriously hindered since many patients experience diarrhea after receiving TKIs. The mechanisms of TKI-associated diarrhea remain unclear. Most existing therapies are symptomatic treatments based on experience and their effects are unsatisfactory. Therefore, clarification of the mechanisms underlying diarrhea is critical to develop effective anti-diarrhea drugs. This article summarizes several potential mechanisms of TKI-associated diarrhea and reviews current treatment progress.

Keywords: Diarrhea; Mechanism; Treatment; Tyrosine kinase inhibitors.

Publication types

Review