Compound C inhibits the replication of feline coronavirus

Yeonjeong Park; Chansoo Kim; Yea-In Park; Siyun Lee; Jaeyeon So; Rackhyun Park; Junsoo Park

doi:10.1016/j.heliyon.2024.e27641

Compound C inhibits the replication of feline coronavirus

Heliyon. 2024 Mar 6;10(6):e27641. doi: 10.1016/j.heliyon.2024.e27641. eCollection 2024 Mar 30.

Authors

Yeonjeong Park¹, Chansoo Kim¹, Yea-In Park¹, Siyun Lee¹, Jaeyeon So¹, Rackhyun Park², Junsoo Park¹

Affiliations

¹ Division of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of Korea.
² Department of Life Science, Yong-In University, Yongin 17092, Republic of Korea.

Abstract

Feline Coronavirus (FCoV) is a viral pathogen of cats and a highly contagious virus. Cats in a cattery can be infected by up to 100%, and even household cats are infected by 20-60%. Some strains of FCoV are known to induce a fatal disease in cats named Feline Infectious Peritonitis (FIP). However, no effective treatments are available. We demonstrated that compound C (dorsomorphin) can potentially inhibit feline coronavirus replication. Compound C treatment decreased the FCoV-induced plaque formation and cytopathic effect in FCoV-infected cells. Compound C treatment also significantly reduced the amount of viral RNA and viral protein in the cells in a dose-dependent manner. Our findings suggest that compound C is potentially useful for feline coronavirus-related diseases.

Keywords: AMPK; Compound C; Feline coronavirus; Feline enteric coronavirus; Feline infectious peritonitis.