Ischemic stroke is currently the most common type of stroke, and the key pathological link is cerebral ischemia-reperfusion injury (CIRI), while the key factor leading to apoptosis and necrosis of ischemic nerve cells is calcium overload. Current studies have confirmed that acupuncture therapy has a good modulating effect on calcium homeostasis and can reduce cerebral ischemia-reperfusion induced damage of neuronal cells by inhibiting calcium overload. After reviewing the relevant literature published in the past 15 years, we find that acupuncture plays a role in regulating the pathological mechanism of calcium overload after CIRI by inhibiting the opening of connexin 43 hemichannels, regulating the intracellular free calcium ion concentration, suppressing the expression of calmodulin, and blocking the function of L-type voltage-gated calcium channels, thereby inhibiting calcium overload, regulating calcium homeostasis and antagonizing neuronal damage resulted from cerebral ischemia-reperfusion, which may provide ideas for future research.
缺血性中风关键病理环节是脑缺血再灌注损伤，而导致缺血性神经细胞凋亡、坏死的关键因素是钙超载。目前研究已证实针刺对钙稳态有良好的调控作用，可以通过抑制钙超载来减轻其对神经细胞的损害。本研究回顾近15年相关文献，分析总结针刺在调控脑缺血再灌注损伤后钙超载的病理机制，包括通过抑制连接蛋白Cx43半通道开放、调控细胞内游离钙浓度、抑制钙调蛋白表达、阻断L-型电压门控钙通道的功能等，进而抑制钙超载，调控钙稳态，拮抗脑缺血再灌注后继发的神经细胞损伤，以期为今后的研究提供思路。.
Keywords: Acupuncture; Calcium overload; Cerebral ischemia-reperfusion injury; Nerve cell.