Bilateral Endoscopic Debridement Combined with Local Antituberculosis Drugs for Thoracic Tuberculosis with Large Paravertebral Abscess: A Multicenter Study with 4-year Follow-Up

World Neurosurg. 2024 May:185:e1160-e1168. doi: 10.1016/j.wneu.2024.03.042. Epub 2024 Mar 16.

Abstract

Background: Paravertebral abscess represents a prevalent manifestation of thoracic tuberculosis, often necessitating surgical intervention. In this study, we introduced a novel approach by employing bilateral endoscopic debridement (BED) to address large Paravertebral abscesses associated with thoracic tuberculosis, a method not previously proposed in the literature. The clinical efficacy was examined through a comprehensive 4-year follow-up.

Methods: We conducted a retrospective analysis on patients diagnosed with thoracic tuberculosis and paravertebral abscess who underwent BED combined with local antituberculosis drugs (BED + LAD) between February 2015 and February 2019. A total of 29 eligible patients (12 males and 17 females) with a median (interquartile ranges) of 59.0(16.5) years were included in the study. All patients received the BED + LAD treatment. After the surgery, the patients were treated with a 4-drug antituberculosis therapy (Rifampicin, Isoniazid, Pyrazinamide, and Ethambutol). All relevant indicators were meticulously recorded and analyzed.

Results: The surgical procedures were successfully completed for all subjects, with an average intraoperative bleeding volume of (25.2 ± 8.9) ml, an average surgical time of (68.4 ± 14.0) minutes, an average fluoroscopy frequency of (21.7 ± 8.2) times, an average hospital stay of (14.2 ± 4.3) days, and an average medication period of (42.1 ± 9.6) weeks. All subjects completed at least a 4-year follow-up period. At the final follow-up, ESR and CRP levels returned to normal, and there was no significant increase in the Cobb angle (P>0.05).

Conclusions: The application of BED + LAD in the treatment of thoracic tuberculosis and paravertebral abscess proved to be a safe, effective, and feasible approach.

Keywords: Bilateral endoscopic; Local antituberculosis drugs; Minimally invasive surgery; Paravertebral abscess; Thoracic tuberculosis.

Publication types

  • Multicenter Study

MeSH terms

  • Abscess / drug therapy
  • Abscess / surgery
  • Adult
  • Aged
  • Antitubercular Agents* / administration & dosage
  • Antitubercular Agents* / therapeutic use
  • Combined Modality Therapy
  • Debridement* / methods
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Neuroendoscopy / methods
  • Retrospective Studies
  • Thoracic Vertebrae / diagnostic imaging
  • Thoracic Vertebrae / surgery
  • Treatment Outcome
  • Tuberculosis, Spinal* / diagnostic imaging
  • Tuberculosis, Spinal* / drug therapy
  • Tuberculosis, Spinal* / surgery

Substances

  • Antitubercular Agents