Metabolic remodeling is a key feature of macrophage activation and polarization. Recent studies have demonstrated the role of tricarboxylic acid (TCA) cycle metabolites in the innate immune system. In the current review, we summarize recent advances in the metabolic reprogramming of the TCA cycle during macrophage activation and polarization and address the effects of these metabolites in modulating macrophage function. Deciphering the crosstalk between the TCA cycle and the immune response might provide novel potential targets for the intervention of immune reactions and favor the development of new strategies for the treatment of infection, inflammation, and cancer.
Keywords: Citrate; Fumarate; Macrophage; Succinate; Tricarboxylic acid cycle metabolites; α-Ketoglutarate.
© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.