CinNapht AIE(E)gens for selective imaging of lipid droplets

Org Biomol Chem. 2024 Apr 3;22(14):2739-2743. doi: 10.1039/d4ob00247d.

Abstract

This article describes the synthesis and photophysical properties of Aggregation-Induced Emission (enhancement) luminogens derivated from CinNaphts dyes. These fluorophores can be obtained in good yields in a single SNAr step of a fluorinated CinNapht derivative by incorporating hindered aromatic amines. They exhibit AIE(E) behavior associated with solid-state fluorescence covering an emission range from 563 to 722 nm. One carbazole derivative demonstrates a remarkable efficiency in imaging lipid droplets in living cells through an original photophysical mechanism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fluorescent Dyes
  • Lipid Droplets*
  • Optical Imaging* / methods

Substances

  • Fluorescent Dyes