Cancer diagnosis and treatment platform based on manganese-based nanomaterials

Jia Fei; Yanyan Liu; Ya Zeng; Mingqi Yang; Shanshan Chen; Xiaobing Duan; Ligong Lu; Muhe Chen

doi:10.3389/fbioe.2024.1363569

Cancer diagnosis and treatment platform based on manganese-based nanomaterials

Front Bioeng Biotechnol. 2024 Mar 1:12:1363569. doi: 10.3389/fbioe.2024.1363569. eCollection 2024.

Authors

Jia Fei¹, Yanyan Liu², Ya Zeng¹, Mingqi Yang², Shanshan Chen², Xiaobing Duan², Ligong Lu², Muhe Chen²

Affiliations

¹ Zhuhai Clinical Medical College of Jinan University (Zhuhai People's Hospital), Zhuhai, China.
² Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai Clinical Medical College of Jinan University, Zhuhai, Guangdong, China.

Abstract

Cancer is a leading cause of death worldwide, and the development of new diagnostic and treatment methods is crucial. Manganese-based nanomaterials (MnNMs) have emerged as a focal point in the field of cancer diagnosis and treatment due to their multifunctional properties. These nanomaterials have been extensively explored as contrast agents for various imaging technologies such as magnetic resonance imaging (MRI), photoacoustic imaging (PAI), and near-infrared fluorescence imaging (NIR-FL). The use of these nanomaterials has significantly enhanced the contrast for precise tumor detection and localization. Moreover, MnNMs have shown responsiveness to the tumor microenvironment (TME), enabling innovative approaches to cancer treatment. This review provides an overview of the latest developments of MnNMs and their potential applications in tumor diagnosis and therapy. Finally, potential challenges and prospects of MnNMs in clinical applications are discussed. We believe that this review would serve as a valuable resource for guiding further research on the application of manganese nanomaterials in cancer diagnosis and treatment, addressing the current limitations, and proposing future research directions.

Keywords: TME (tumor microenvironment); cancer diagnosis; cancer treatment; manganese nanomaterials; nanomaterials; tumor.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work is supported by the National Natural Science Foundation of China (82230067, 82103433), Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment (2021B1212040004), Zhuhai Industrial Core and Key Technology Tackling Direction Project (ZH22044702190126HJL).