FIRRM and FIGNL1: partners in the regulation of homologous recombination

Stavroula Tsaridou; Marcel A T M van Vugt

doi:10.1016/j.tig.2024.02.007

FIRRM and FIGNL1: partners in the regulation of homologous recombination

Trends Genet. 2024 Mar 16:S0168-9525(24)00048-9. doi: 10.1016/j.tig.2024.02.007. Online ahead of print.

Authors

Stavroula Tsaridou¹, Marcel A T M van Vugt²

Affiliations

¹ Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713GZ, Groningen, The Netherlands.
² Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713GZ, Groningen, The Netherlands. Electronic address: m.vugt@umcg.nl.

PMID: 38494375
DOI: 10.1016/j.tig.2024.02.007

Abstract

DNA repair through homologous recombination (HR) is of vital importance for maintaining genome stability and preventing tumorigenesis. RAD51 is the core component of HR, catalyzing the strand invasion and homology search. Here, we highlight recent findings on FIRRM and FIGNL1 as regulators of the dynamics of RAD51.

Keywords: C1orf112; FIGNL1; FIRRM; RAD51; homologous recombination.