Updates to the Melbourne Children's Regional Infant Brain Software Package (M-CRIB-S)

Chris L Adamson; Bonnie Alexander; Claire E Kelly; Gareth Ball; Richard Beare; Jeanie L Y Cheong; Alicia J Spittle; Lex W Doyle; Peter J Anderson; Marc L Seal; Deanne K Thompson

doi:10.1007/s12021-024-09656-8

Updates to the Melbourne Children's Regional Infant Brain Software Package (M-CRIB-S)

Neuroinformatics. 2024 Apr;22(2):207-223. doi: 10.1007/s12021-024-09656-8. Epub 2024 Mar 16.

Authors

Chris L Adamson¹, Bonnie Alexander¹, Claire E Kelly^{1

2}, Gareth Ball¹, Richard Beare^{1

3}, Jeanie L Y Cheong^{1

4

5}, Alicia J Spittle^{1

4

6}, Lex W Doyle^{1

4

5

7}, Peter J Anderson^{1

2

7}, Marc L Seal^{1

7}, Deanne K Thompson^{8

9

10

11}

Affiliations

¹ Royal Children's Hospital, Murdoch Children's Research Institute, Flemington Road, Parkville, Victoria, 3052, Australia.
² Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Australia.
³ Department of Medicine, Monash University, Melbourne, Australia.
⁴ Neonatal Services, The Royal Women's Hospital, Melbourne, Australia.
⁵ Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia.
⁶ Department of Physiotherapy, The University of Melbourne, Melbourne, Australia.
⁷ Department of Paediatrics, The University of Melbourne, Melbourne, Australia.
⁸ Royal Children's Hospital, Murdoch Children's Research Institute, Flemington Road, Parkville, Victoria, 3052, Australia. deanne.thompson@mcri.edu.au.
⁹ Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Australia. deanne.thompson@mcri.edu.au.
¹⁰ Department of Paediatrics, The University of Melbourne, Melbourne, Australia. deanne.thompson@mcri.edu.au.
¹¹ Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia. deanne.thompson@mcri.edu.au.

Abstract

The delineation of cortical areas on magnetic resonance images (MRI) is important for understanding the complexities of the developing human brain. The previous version of the Melbourne Children's Regional Infant Brain (M-CRIB-S) (Adamson et al. Scientific Reports, 10(1), 10, 2020) is a software package that performs whole-brain segmentation, cortical surface extraction and parcellation of the neonatal brain. Available cortical parcellation schemes in the M-CRIB-S are the adult-compatible 34- and 31-region per hemisphere Desikan-Killiany (DK) and Desikan-Killiany-Tourville (DKT), respectively. We present a major update to the software package which achieves two aims: 1) to make the voxel-based segmentation outputs derived from the Freesurfer-compatible M-CRIB scheme, and 2) to improve the accuracy of whole-brain segmentation and cortical surface extraction. Cortical surface extraction has been improved with additional steps to improve penetration of the inner surface into thin gyri. The improved cortical surface extraction is shown to increase the robustness of measures such as surface area, cortical thickness, and cortical volume.

Keywords: Baby; Cortical; Gyrus; Magnetic resonance imaging; Neonate; Segmentation; Sulcus.

MeSH terms

Adult
Brain* / diagnostic imaging
Cerebral Cortex* / diagnostic imaging
Child
Humans
Infant, Newborn
Magnetic Resonance Imaging / methods
Software