Polymorphism in Genes Encoding Adaptor Proteins ST13 and STIP1 and the Risk of Ischemic Stroke: a Pilot Study

T A Stetskaya; A B Krapiva; K A Kobzeva; D E Gurtovoy; G V Komkova; A V Polonikov; O Yu Bushueva

doi:10.1007/s10517-024-06050-x

Polymorphism in Genes Encoding Adaptor Proteins ST13 and STIP1 and the Risk of Ischemic Stroke: a Pilot Study

Bull Exp Biol Med. 2024 Feb;176(4):477-480. doi: 10.1007/s10517-024-06050-x. Epub 2024 Mar 16.

Authors

T A Stetskaya¹, A B Krapiva², K A Kobzeva², D E Gurtovoy², G V Komkova³, A V Polonikov^{1

3}, O Yu Bushueva^{4

5}

Affiliations

¹ Laboratory of Statistical Genetics and Bioinformatics, Research Institute of Genetics and Molecular Epidemiology, Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
² Laboratory of Genomic Research, Research Institute of Genetic and Molecular Epidemiology, Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
³ Department of Biology, Medical Genetics, and Ecology, Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
⁴ Laboratory of Genomic Research, Research Institute of Genetic and Molecular Epidemiology, Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia. olga.bushueva@inbox.ru.
⁵ Department of Biology, Medical Genetics, and Ecology, Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia. olga.bushueva@inbox.ru.

PMID: 38492099
DOI: 10.1007/s10517-024-06050-x

Abstract

Adaptor proteins stress induced phosphoprotein 1 (STIP1) and ST13 Hsp70 interacting protein (ST13) may play a crucial role in the pathophysiology of ischemic stroke through controlling protein folding, neuronal survival, and regulation of HSP70/HSP90. The present pilot study investigated whether tagSNPs in genes encoding ST13 (rs138335, rs138344, rs7290793, and rs138344) and STIP1 (rs4980524) are associated with ischemic stroke. DNA samples from 721 ischemic stroke patients and 471 healthy controls were genotyped using the MassArray-4. Our research revealed a relationship between rs138344 ST13 and the risk of ischemic stroke, which was seen only in females (risk allele G; OR=1.34, 95%CI=1.07-1.69; p=0.01). The haplotype rs138335G-rs138344C-rs7290793C ST13 was linked with lower risk of ischemic stroke in females: OR=0.42; 95%CI=0.26-0.68; p=0.0005. Thus, ST13 represents a novel genetic marker for ischemic stroke.

Keywords: ST13; STIP1; heat shock proteins; ischemic stroke; rs138344.

MeSH terms

Female
Genotype
HSP70 Heat-Shock Proteins / metabolism
Heat-Shock Proteins* / genetics
Humans
Ischemic Stroke*
Molecular Chaperones* / genetics
Pilot Projects
Polymorphism, Genetic
Tumor Suppressor Proteins* / genetics

Substances

Heat-Shock Proteins
HSP70 Heat-Shock Proteins
Molecular Chaperones
ST13 protein, human
STIP1 protein, human
Tumor Suppressor Proteins