Dual role of mesenchymal stem/stromal cells and their cell-free extracellular vesicles in colorectal cancer

Mohamed J Saadh; Asma'a H Mohamed; Muhammad Ali Abdullah Almoyad; Omer Qutaiba B Allela; Ali H Amin; April Ann Malquisto; Wong Tze Jin; Ioan Sârbu; Faisal AlShamsi; Fahmy Gad Elsaid; Reza Akhavan-Sigari

doi:10.1002/cbf.3962

Dual role of mesenchymal stem/stromal cells and their cell-free extracellular vesicles in colorectal cancer

Cell Biochem Funct. 2024 Mar;42(2):e3962. doi: 10.1002/cbf.3962.

Authors

Mohamed J Saadh^{1

2}, Asma'a H Mohamed³, Muhammad Ali Abdullah Almoyad⁴, Omer Qutaiba B Allela⁵, Ali H Amin⁶, April Ann Malquisto^{7

8

9}, Wong Tze Jin^{10

11}, Ioan Sârbu¹², Faisal AlShamsi¹³, Fahmy Gad Elsaid¹⁴, Reza Akhavan-Sigari^{15

16}

Affiliations

¹ Faculty of Pharmacy, Middle East University, Amman, Jordan.
² Applied Science Research Center, Applied Science Private University, Amman, Jordan.
³ Biomedical Engineering Department, College of Engineering and Technologies, Al-Mustaqbal University, Babil, Hilla, Iraq.
⁴ Department of Basic Medical Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Mushait, Saudi Arabia.
⁵ Department of Pharmacy, Al-Noor University College, Nineveh, Iraq.
⁶ Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
⁷ Abuyog Community College, Abuyog Leyte, Philippines.
⁸ ESL Science Teacher, Tacloban City, Tacloban, Philippines.
⁹ Department of Art Sciences and Education, Tacloban City, Philippines.
¹⁰ Department of Science and Technology, Faculty of Humanities, Management and Science, Universiti Putra Malaysia Bintulu Campus, Sarawak, Malaysia.
¹¹ Institute for Mathematical Research, Universiti Putra Malaysia, Selangor, Malaysia.
¹² 2nd Department of Surgery-Pediatric Surgery and Orthopedics, "Grigore T. Popa" University of Medicine and Pharmacy, Romania.
¹³ Dubai Health Authority, Primary Health Care Department, Dubai, United Arab Emirates.
¹⁴ Biology Department, College of Science, King Khalid University, Asir, Abha, Al-Faraa, Saudi Arabia.
¹⁵ Department of Neurosurgery, University Medical Center Tuebingen, Tuebingen, Germany.
¹⁶ Department of Health Care Management and Clinical Research, Collegium Humanum Warsaw Management University, Warsaw, Poland.

PMID: 38491792
DOI: 10.1002/cbf.3962

Abstract

Colorectal cancer (CRC) is one of the main causes of cancer-related deaths. However, the surgical control of the CRC progression is difficult, and in most cases, the metastasis leads to cancer-related mortality. Mesenchymal stem/stromal cells (MSCs) with potential translational applications in regenerative medicine have been widely researched for several years. MSCs could affect tumor development through secreting exosomes. The beneficial properties of stem cells are attributed to their cell-cell interactions as well as the secretion of paracrine factors in the tissue microenvironment. For several years, exosomes have been used as a cell-free therapy to regulate the fate of tumor cells in a tumor microenvironment. This review discusses the recent advances and current understanding of assessing MSC-derived exosomes for possible cell-free therapy in CRC.

Keywords: cell-free therapy; colorectal cancer; exosomes; extracellular vesicles; mesenchymal stromal cells.

Publication types

Review

MeSH terms

Cell Communication
Colorectal Neoplasms*
Exosomes*
Extracellular Vesicles*
Humans
Mesenchymal Stem Cells*
Tumor Microenvironment

Grants and funding

R.G.P.2/61/45/Deanship of Scientific Research at King Khalid University