ncRS: A resource of non-coding RNAs in sepsis

Comput Biol Med. 2024 Apr:172:108256. doi: 10.1016/j.compbiomed.2024.108256. Epub 2024 Mar 11.

Abstract

Sepsis, a life-threatening condition triggered by the body's response to infection, presents a significant global healthcare challenge characterized by disarrayed host responses, widespread inflammation, organ impairment, and heightened mortality rates. This study introduces the ncRS database (http://www.ncrdb.cn), a meticulously curated repository housing 1144 experimentally validated non-coding RNAs (ncRNAs) intricately linked with sepsis. ncRS offers comprehensive RNA data, exhaustive experimental insights, and integrated annotations from diverse databases. This resource empowers researchers and clinicians to decipher ncRNAs' roles in sepsis pathogenesis, potentially identifying vital biomarkers for early diagnosis and prognosis, thus facilitating personalized treatments.

Keywords: Biomarker; Non-coding RNA; Pathogenesis; Sepsis; ncRS database.

MeSH terms

  • Biomarkers
  • Databases, Nucleic Acid
  • Humans
  • RNA, Untranslated* / genetics
  • Sepsis* / genetics

Substances

  • RNA, Untranslated
  • Biomarkers